Clinical Trials Logo

Clinical Trial Summary

Recently there was described an increase in left ventricular mass after kidney donation. It is uncertain whether this is reversible or not. Allopurinol lowers uric acid in the blood and is normally indicated for gout, but studies have showed that it also can reduce the thickness of the left ventricle of the heart in people with heart- and kidney disease. The investigators wish to give allopurinol or placebo to kidney donors based on randomization and investigate if this has the same effect on kidney donors. The investigators are assessing this by performing a cardiac MRI at baseline and after 9 months of treatment. In addition the investigators wish to see if allopurinol can have beneficial effects on blood pressure and insulin sensitivity as well.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Renal Transplant Donor of Left Kidney
  • Renal Transplant Donor of Right Kidney

NCT number NCT03353298
Study type Interventional
Source Oslo University Hospital
Contact
Status Completed
Phase Phase 2
Start date January 17, 2018
Completion date September 25, 2020

See also
  Status Clinical Trial Phase
Completed NCT06197620 - Effectiveness of Thread Embedding Acupuncture Analgesia at the EX-B2 Point Combined With Standard Therapy After Laparoscopic Living Donor Nephrectomy N/A
Completed NCT02838134 - Deep Versus Moderate Muscle Relaxation During Laparoscopic Donor Nephrectomy in Enhancing Postoperative Recovery Phase 4
Active, not recruiting NCT02811835 - TransplantLines Food and Nutrition Biobank and Cohort Study (TxL-FN) N/A
Terminated NCT06458842 - Postoperative Pain Protocol Limiting Narcotics for Laparoscopic Hand-assisted Donor Nephrectomy N/A
Completed NCT03520205 - Quadratus Lumborum Block Versus Epidural for Laparoscopic Nephrectomy Kidney Donor N/A
Completed NCT04810884 - Fractures and Bone Disease in Living Kidney Donors
Completed NCT01925677 - Robotic Single Port Donor Nephrectomy N/A
Completed NCT02699489 - Enhanced Recovery Open Versus Laparoscopic Donor Nephrectomy Phase 3