Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population

The Recipients Undergoing Liver Transplantation Clinical Trial

Official title:

Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03344380
• Other study ID #: 4-2017-0888
• Status: Recruiting
• Start date: November 1, 2017
• Est. completion date: December 2020

Study information

• Verified date: January 2019
• Source: Yonsei University
• Contact: Seung Ho Choi, MD
• Phone: +82-2-2228-2420
• Email: csho99[@]yuhs.ac
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors. Prevention of postoperative acute kidney injury is essential for postoperative care in liver transplantation recipients. The aim of this study is to investigate the relationship between gene polymorphisms and the occurrence of acute kidney injury after liver transplantation by performing genome-wide association study (GWAS).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 330
• Est. completion date: December 2020
• Est. primary completion date: November 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 80 Years

Eligibility

Inclusion Criteria:

1) adult patients scheduled for liver transplantation

Exclusion Criteria:

1. Patients on dialysis

2. patients not able to read, or understand the consent form

3. ethnicity, other than asian

4. patients refusal

Related Conditions & MeSH terms

• Acute Kidney Injury
• The Recipients Undergoing Liver Transplantation

Locations

Country	Name	City	State
Korea, Republic of	Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Acute kidney injury after liver transplantation	The development of acute kidney injury is defined by the following definition: 50% increase in SCr from the baseline (preoperative value) or a 0.3 mg/dl increase from baseline within 48 h without urine output. The development of acute kidney injury after liver transplantation could correlate with gene polymorphisms, which have been known to be associated with postoperative acute kidney injury.	Participants will be followed up during the first 72 hours post-liver transplantation in order to confirm the development of acute kidney injury.