Complication of Surgical Procedure Clinical Trial
Official title:
Outcomes of Surgical Correction of Penile Curvature in Adult
Penile curvature in adults is divided into two main categories the first is congenital penile
curvature with orthotopic meatus and the other is acquired curvature which its common causes
are Peyronie's disease (PD) and previous penile surgery as for hypospadias repair.The
congenital penile curvatures (CPC) which not associated with urethral malformation is a
relatively uncommon condition that may present in late adolescent or early adult life. The
incidence is estimated to be 0.6 % but the incidence of clinically significant CPC is much
lower, as the degree of curvature and sexual dysfunction varies widely Penile curvature may
lead to inability for sexual intercourse. These cases require treatment. Acquired penile
curvature its most common cause is Peyronie's disease. Peyronie's disease is a fibrotic
disorder of the tunica albuginea of the corpora cavernosa that is clinically defined by the
presence of a palpable, inelastic tunical plaque. PD is relatively common and affects up to
20.3% of adult men to some degree.
Surgery is gold-standard for treatment of curvature in stable PD. Surgical therapy is
subdivided into three main procedures: (1) plication techniques (Penile shortening
procedures), (2) grafting procedures with partial plaque excision or incision followed by
defect closure with various grafts, and (3) correction of deviation with simultaneous penile
prosthesis implantation in patients with ED not responding to medical therapy.
In this study results of different surgical techniques in management of penile curvature will
be compared.
Status | Not yet recruiting |
Enrollment | 50 |
Est. completion date | December 1, 2020 |
Est. primary completion date | November 1, 2020 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - penile curvature more than 30degree. Exclusion Criteria: - Age: less than 18 years. - Non-orthotopic meatus - Patients with ED. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Bar Yosef Y, Binyamini J, Matzkin H, Ben-Chaim J. Midline dorsal plication technique for penile curvature repair. J Urol. 2004 Oct;172(4 Pt 1):1368-9. — View Citation
Devine CJ Jr, Horton CE. Chordee without hypospadias. J Urol. 1973 Aug;110(2):264-71. — View Citation
Donnahoo KK, Cain MP, Pope JC, Casale AJ, Keating MA, Adams MC, Rink RC. Etiology, management and surgical complications of congenital chordee without hypospadias. J Urol. 1998 Sep;160(3 Pt 2):1120-2. — View Citation
Kramer SA, Aydin G, Kelalis PP. Chordee without hypospadias in children. J Urol. 1982 Sep;128(3):559-61. — View Citation
Makovey I, Higuchi TT, Montague DK, Angermeier KW, Wood HM. Congenital penile curvature: update and management. Curr Urol Rep. 2012 Aug;13(4):290-7. doi: 10.1007/s11934-012-0257-x. Review. — View Citation
Nehra A, Alterowitz R, Culkin DJ, Faraday MM, Hakim LS, Heidelbaugh JJ, Khera M, Kirkby E, McVary KT, Miner MM, Nelson CJ, Sadeghi-Nejad H, Seftel AD, Shindel AW, Burnett AL; American Urological Association Education and Research, Inc.,. Peyronie's Diseas — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Correcting the curvature. | Measure of any residual curvature present by using the protractor. | 3 months postoperative | |
Primary | Preserving erectile function and hardness. | to show any affection of erectile function by using Interarnational index of Erectile dysfunction questionnaire. | 4 months | |
Primary | Preserving penile length. | to measure penile length postoperative and compare to the preoperative length | 3 months | |
Primary | Penile sensation. | To show any affection of penile sensation postoperative | 3 months |
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