Leber Hereditary Optic Neuropathy Clinical Trial
Official title:
Observational Registry Study of Leber Hereditary Optic Neuropathy (LHON) Affected Patients
This study is a multi-country retrospective and cross-sectional observational study of affected LHON subjects, based on retrospective subjects' medical chart abstractions and cross-sectional administration of patient-reported outcomes (PROs).
The purpose of this study is to understand the evolution of visual functional and structural changes and other associated symptoms in patients with LHON. The relation between genetic, lifestyle and/or environmental factors and the LHON disease will be described, and a better understanding of the natural history of LHON disease and the healthcare associated to with the disease will be sought. In addition, we would also like to understand the economic burden for patients and their families with LHON resulting from direct and indirect costs they may have because of their disease. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03475173 -
New Non-invasive Modalities for Assessing Retinal Structure and Function
|
N/A | |
| Active, not recruiting |
NCT03293524 -
Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year
|
Phase 3 | |
| Recruiting |
NCT02176733 -
Trial of Cyclosporine in the Acute Phase of Leber Hereditary Optic Neuropathy
|
Phase 2 | |
| Completed |
NCT03406104 -
RESCUE and REVERSE Long-term Follow-up
|
Phase 3 | |
| Recruiting |
NCT03011541 -
Stem Cell Ophthalmology Treatment Study II
|
N/A | |
| Completed |
NCT02064569 -
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT03153293 -
A Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic Neuropathy
|
Phase 2/Phase 3 | |
| Completed |
NCT01267422 -
Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON)
|
N/A |