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NCT03230617 Clinical Trial

Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

Pulmonary Disease, Chronic Obstructive Clinical Trial

Official title:
Evaluation Of Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT03230617
Other study ID # EDHMVCP
Secondary ID
Status Not yet recruiting
Phase N/A
First received July 24, 2017
Last updated July 25, 2017
Start date September 1, 2017
Est. completion date December 31, 2018

Study information
Verified date July 2017
Source Assiut University
Contact Suzan Salama, MSc
Phone 0101423616
Email Suzansalama61@yahoo.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Chronic obstructive pulmonary disease is a common respiratory condition that is characterized by inflammation of the large and small peripheral airways , the alveoli and adjacent capillary networks. Severe airflow obstruction that imposes a significant load on the respiratory system is a major manifestation of Chronic obstructive pulmonary disease. The reduced expiratory airflow also causes air trapping at the end of expiration , producing alveolar pressure that are higher than atmospheric pressure before the next breath. This condition is intrinsic positive end-expiratory pressure .

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 100
Est. completion date December 31, 2018
Est. primary completion date September 1, 2018
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- patient with acute exacerbation of Chronic obstructive pulmonary disease and respiratory failure who are intubated and mechanically ventilated.

Exclusion Criteria:

- patient with neuromuscular diseases.

- patient with pulmonary vascular diseases e.g pulmonary embolism.

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• Mechanical ventilator
Mechanical ventilation, in the healthcare setting or home, helps patients breathe by assisting the inhalation of oxygen into the lungs and the exhalation of carbon dioxide. Depending on the patient's condition, mechanical ventilation can help support or completely control breathing.

Locations
Country Name City State
Egypt Assiut University Assiut

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Reddy VG. Auto-PEEP: how to detect and how to prevent--a review. Middle East J Anaesthesiol. 2005 Jun;18(2):293-312. Review. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary The duration of mechanical ventilation 1 month
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