Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury can be improved through a form of mental coaching and encouragement, known as operant conditioning.


Clinical Trial Description

Thigh muscle weakness is a common result after anterior cruciate ligament (ACL) injury and reconstruction surgery. Therefore, reducing thigh muscle weakness after ACL injury and reconstructive surgery is important as the quadriceps muscles act as shock absorbers that protect the knee joint. If significant weakness is present in the quadriceps, the knee is exposed to increased forces and often results in degeneration of the structures in the joint leading to osteoarthritis. Thus, it is important to investigate activation and strength rehabilitation methods for the quadriceps muscles. This research study is being done to learn if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury can be improved by conditioning brain responses (elicited by non-invasive transcranial magnetic stimulation) using a form of training called as operant conditioning. ;


Study Design


Related Conditions & MeSH terms

  • Anterior Cruciate Ligament Injuries
  • Anterior Cruciate Ligament Injury

NCT number NCT03209531
Study type Interventional
Source University of Michigan
Contact Chandramouli Krishnan, PhD
Phone 734.936.4031
Email mouli@umich.edu
Status Recruiting
Phase N/A
Start date September 21, 2017
Completion date September 2026

See also
  Status Clinical Trial Phase
Recruiting NCT05527171 - Virtual Reality Mindfulness Meditation After ACL Reconstruction N/A
Completed NCT03130049 - Popliteal Plexus Block for Postoperative Pain After ACL Reconstruction N/A
Withdrawn NCT01433718 - Decreasing Knee Injury Risk Factors With Neuromuscular Training N/A
Active, not recruiting NCT00529958 - Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction N/A
Active, not recruiting NCT03292926 - A Novel Analgesia Technique for ACL Reconstruction Phase 4
Recruiting NCT03700996 - Clinical Outcome Following Arthroscopic Knee Surgery
Active, not recruiting NCT02931084 - Natural Course and Recovery After ACL-injury
Terminated NCT01377129 - Anterior Cruciate Ligament Reconstruction: Residual Rotational Laxity for Single Versus Double Bundle Techniques N/A
Completed NCT04461145 - Effect of Dual Tasks on Gait Symmetry After Anterior Cruciate Ligament Reconstruction N/A
Enrolling by invitation NCT04650568 - Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction N/A
Recruiting NCT03740022 - ACL Versus ALL + ACL Study N/A
Active, not recruiting NCT02310854 - Acute Anterior Cruciate Ligament Rupture; RecOnsTruction Or Repair? N/A
Completed NCT03617991 - Functional and Self-reported Outcomes in Participants With a History of Musculoskeletal Knee Injury N/A
Completed NCT03711734 - Acupuncture ACL (Anterior Cruciate Ligament) N/A
Completed NCT03680716 - Combined Saphenous Nerve and IPACK Blocks Versus Infiltration Analgesia After Anterior Cruciate Ligament Reconstruction N/A
Active, not recruiting NCT03200678 - WEakness and Atrophy: isoKinetic With Surface Electromyography Assessment in ACL Surgery N/A
Completed NCT02530333 - Differential Biomechanical Effects of an ACL Injury Prevention Program in Women's Basketball and Soccer Players N/A
Active, not recruiting NCT02111759 - The Effect of Knee Flexion Angle for Graft Fixation During Single-Bundle Anterior Cruciate Ligament Reconstruction N/A
Completed NCT03473873 - Protective Role of Muscle Function for Early Features of Knee Osteoarthritis After Anterior Cruciate Ligament Injury
Active, not recruiting NCT03473821 - Motor Imagery to Facilitate Sensorimotor Relearning After ACL Injury N/A