Other Clinical Trial - Attenuation of Hemodynamic Response NCT03204006

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Clinical Trial Details — Status: Completed

Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.

Recruitment information / eligibility
Status	Completed
Enrollment	70
Est. completion date	March 12, 2020
Est. primary completion date	March 8, 2020
Accepts healthy volunteers	No
Gender	All
Age group	20 Years to 60 Years
Eligibility	Inclusion Criteria: - - Age group 20-60 years - ASA grade 1 and 2 - control hypertensive patients. Exclusion Criteria: - - Consent not given - ASA Grade 3 and 4 - history of myocardial ischemia or infarction, or had an abnormal ECG on admission to the hospital - Patients with cardiovascular, pulmonary, hepatic, and renal disease. - Patients on B blockers. - patients with difficult airway; laryngoscopy and intubation time more than 20 s, or requiring more than two attempts will be exclude from the study.

Drug:
• Dexmedetomidine
Dexmedetomidine preinduction
• sterile saline
normal saline preinduction

Locations
Country	Name	City	State
Egypt	Assiut University Hospital	Assiut

Sponsors *(1)*
Lead Sponsor	Collaborator
Assiut University

Egypt,

Outcome
Type	Measure	Time frame
Primary	heart rate	through first 15 min post-induction of anesthesia
Secondary	systolic blood pressure	through first 15 min post-induction of anesthesia
Secondary	diastolic blood pressure	through first 15 min post-induction of anesthesia