Gram-negative Bacterial Infections Clinical Trial
Official title:
A Non-Randomized, Open Label, One Treatment, One Group Study to Investigate the Intrapulmonary Lung Penetration of RO7079901 in Healthy Volunteers
The purpose of this study is to characterize the intrapulmonary penetration of nacubactam in healthy volunteers. Nacubactam is a novel non-beta-lactam beta-lactamase inhibitor being developed as a combination therapy with the beta-lactam meropenem for the treatment of serious gram-negative bacterial infections. Adult male and female healthy participants will receive a single intravenous infusion of nacubactam co-administered with meropenem and then undergo a bronchoalveolar lavage (BAL) procedure to collect lung epithelial lining fluid (ELF) for measurement of intrapulmonary concentrations of nacubactam and meropenem.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00723502 -
Efficacy and Safety Study of Finafloxacin Used in Helicobacter Pylori Infected Patients
|
Phase 2 | |
| Completed |
NCT00177814 -
Piperacillin as a Part of Antibiotic Streamlining in the Intensive Care Unit
|
||
| Suspended |
NCT00563134 -
A Randomised Trial on the Saftely and Efficacy of GR270774 in the Treatment of Gram-negative Sepsis in Adult
|
N/A | |
| Active, not recruiting |
NCT05171257 -
Quantifying Gram-negative Resistance to Empiric Therapy in the Intensive Care Unit
|
||
| Completed |
NCT03160040 -
A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Minocin® (Minocycline) for Infections Caused by Gram-negative Bacteria in a Real World Setting
|
||
| Completed |
NCT02962934 -
An Observational Pharmacokinetic Sudy of Ceftolozane-Tazobactam in Intensive Care Unit in Patients With and Without CRRT
|
||
| Not yet recruiting |
NCT06135350 -
Clinical Trial to Study the Efficacy and Safety of Fluorothiazinone (N.F. Gamaleya NRCEM) in Prophylaxis of Nosocomial Bacterial Infections With Participation of Patients on MV
|
Phase 2 | |
| Enrolling by invitation |
NCT04055922 -
Comparison of Solid Organ Transplant
|
||
| Completed |
NCT00490477 -
The Effects of Polymyxin-B Protects on Sepsis Induced Kidney Dysfunction: a Randomized Clinical Trial
|
Phase 3 | |
| Recruiting |
NCT04861922 -
Unfractioned Heparin for Treatment of Sepsis Caused by Abdominal Infection
|
Phase 3 | |
| Completed |
NCT01732250 -
Multicenter Open-label Randomized Controlled Trial (RCT) to Compare Colistin Alone Versus Colistin Plus Meropenem
|
Phase 4 | |
| Completed |
NCT00406198 -
Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis
|
Phase 4 | |
| Recruiting |
NCT06086626 -
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants
|
Phase 2 | |
| Withdrawn |
NCT04785924 -
Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE Infections
|
Phase 4 | |
| Completed |
NCT02285075 -
Temocillin Pharmacokinetic in Hemodialysis
|
Phase 4 | |
| Not yet recruiting |
NCT04917380 -
The Clinical Character，Risk and Prognosis of Post-neurosurgical Intracranial Infection With Different Pathogens.
|
||
| Terminated |
NCT05210387 -
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections
|
N/A | |
| Completed |
NCT03397914 -
Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infections
|
Phase 4 | |
| Completed |
NCT02088840 -
Survey of Severe Infections by Gram Negative Bacteria in Patients Submitted to Stem Cell Transplant
|
||
| Recruiting |
NCT01600768 -
Evaluation of Extended Intravenous of Beta-lactams in the Treatment of Serious Gram-negative Infections in Critically Ill Patients
|
N/A |