Twin Pregnancy With Antenatal Problem Clinical Trial
Official title:
Austrian Registry on the Outcome of Monochorionic Multiple Pregnancies: A Multicenter Registry Study
About one third of twin pregnancies are resulting from a single fertilized oocyte. Two third
of these monozygotic twins share a common placenta and are therefore called monochorionic.
Due to placental sharing and the ever-present inter-fetal vascular connections, specific
complications may arise and lead to an increased risk of intrauterine death and long-term
neurodevelopmental impairment. Specific complications include twin-to-twin transfusion
syndrome (TTTS), twin-anemia-polycythemia sequence (TAPS), selective intrauterine growth
restriction (sIUGR) and discordant major anomalies, occurring in about 10%, 5%, 20% and 6%
of monochorionic diamniotic twins. Prenatal interventions may improve perinatal and
long-term outcome of affected fetuses. However, general knowledge about early diagnosis of
monochorionic twins and their specific complications is still limited in a significant
number of practitioners in Austria and systematic analysis of pregnancy outcomes are not
conducted.
In this prospective multicenter registry study, the investigators aim to include all
monochorionic pregnancies in Austria. Main outcome parameter is the occurrence of
complications. Secondary outcomes are gestational age at occurrence of complications,
gestational age delivery and neonatal outcome. The investigators also strive for long-term
outcome, especially of infants following complicated pregnancies or preterm birth.
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