Mechanical Ventilation Parameters in HAP Patients

Mechanical Ventilation Pressure High Clinical Trial

Official title:

Nosocomial Pneumonia as a Factor Influencing Parameters of Mechanical Ventilation: Results of a Retrospective, Observational Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03111303
• Other study ID #: 65/16
• Status: Completed
• Phase: N/A
• First received: April 7, 2017
• Last updated: October 24, 2017
• Start date: January 1, 2011
• Est. completion date: April 6, 2017

Study information

• Verified date: October 2017
• Source: University Hospital Olomouc
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Hospital-acquired pneumonia (HAP) in patients in intensive care often requires the mechanical ventilation (MV). Management and weaning from MV are given by specificity of this type of pulmonary inflammation. Enrolled in the retrospective, observational study were all patients older than 18 years staying at the ICU of University Hospital in Olomouc, between 1 January 2011 and 31 December 2016. The determination of the parameters of the MV, ICU length of stay, hospital length of stay and mortality in HAP group were compared with the control group of patients without HAP.

Description:

Hospital-acquired pneumonia (HAP) development influences the parameters of mechanical ventilation, intensive care unit (ICU) length of stay, hospital length of stay, need of tracheostomy, bronchoscopy, reconnection to MV and mortality. We respect HAP definition: acute inflammation of the respiratory bronchioles, alveolar structures and pulmonary interstitium. Clinically it is defined as the presence of newly developed or progressive infiltrates on chest radiographs plus at least two other signs of respiratory tract infection: temperature >38 °C, chest pain, purulent sputum, leukocytosis or leukopenia, signs of inflammation on auscultation, cough and/or respiratory insufficiency. HAP is defined as pneumonia that occurs 48 hours or more after admission, which was not incubating at the time of admission. A retrospective, observational study processing data on all consecutive intensive care patients older than 18 years of age between 1 January 2011 and 31 December 2015. The aim was to determine the incidence of potential risk factors and their impact on the development of HAP. The primary outcome was investigation of the relationship between mechanical ventilation parameters and the presence of early- and late-onset HAP. Enrolled in the study were patients staying at the ICU of the Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, between 1 January 2011 and 31 December 2016. The participants were all patients older than 18 years of age consecutively admitted to the ICU.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2654
• Est. completion date: April 6, 2017
• Est. primary completion date: December 31, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age 18+

• Need of Mechanical ventilation (Pressure controlled mechanical ventilation or Pressure support ventilation)

Exclusion Criteria:

• Organ donor

• Need Volume controlled mechanical ventilation

• no mechanical ventilation

Related Conditions & MeSH terms

• Mechanical Ventilation Pressure High

Intervention

Device:
• mechanical ventilation
Connection to mechanical ventilator

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital Olomouc

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Inspiratory pressure	most high inspiratory pressure during MV	during MV
Other	Positive end expiratory pressure (PEEP)	most high PEEP during MV	during MV
Primary	length of mechanical ventilation	days of MV	during MV
Secondary	ICU length of stay	length of stay in ICU	1 month
Secondary	Hospital length of stay (LOS)	length of hospital stay	1 month
Secondary	Mortality	mortality during Hospital LOS	1 month