Hematopoietic Stem Cell Transplantation Clinical Trial
Official title:
Mesenchymal Stem Cell Infusion in Haploidentical Hematopoietic Stem Cell Transplantation in Patients With Hematological Malignancies
Verified date | January 2018 |
Source | Ankara University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Mesenchymal stem cells (MSCs) have been used in the treatment and prevention of graft-versus host disease (GVHD). In this study the investigators aim to present the efficacy of mesenchymal stem cells in graft versus host disease prophylaxis and effect of engraftment in haploidentical recipients. Forty patients aged older than 18 who have indications for haploidentical hematopoietic stem cell transplantation will be included to the study. MSCs will be isolated from donor bone marrows and infused to the patient after conditioning regimen on day +6. If the haploidentical transplantation results improve with MSCs treatment it would be possible to ameliorate the problem of HLA-matched donor paucity in Turkey and prefer haploidentical donors.
Status | Completed |
Enrollment | 6 |
Est. completion date | October 2017 |
Est. primary completion date | July 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Diagnosed with haematological malignancy - Indication of haploidentical hematopoietic stem cell transplantation - No restrictions for transplantation Exclusion Criteria: - Any restriction for transplantation - No indication of haploidentical hematopoietic stem cell transplantation |
Country | Name | City | State |
---|---|---|---|
Turkey | Ankara University School of Medicine Department of Hematology | Ankara |
Lead Sponsor | Collaborator |
---|---|
Ankara University | The Scientific and Technological Research Council of Turkey |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Effect of mesenchymal stem cells on overall survival in haploidentical stem cell transplantation | 36 months | ||
Secondary | Effect of mesenchymal stem cells on graft versus host disease incidence in haploidentical stem cell transplantation | 36 months | ||
Secondary | Effect of mesenchymal stem cells on graft failure incidence in haploidentical stem cell transplantation | 36 months |
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