Aspirin in Asymmetrically Intrauterine Growth

Intrauterine Growth Restriction Asymmetrical Clinical Trial

Official title:

Effect of Low-dose Aspirin on Fetal Weight of Idiopathic Asymmetrically Intrauterine Growth Restricted Fetuses With Abnormal Umbilical Doppler Indices

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03038607
• Other study ID #: ASP
• Status: Completed
• Phase: Phase 2
• First received: January 29, 2017
• Last updated: January 29, 2017
• Start date: January 2016
• Est. completion date: January 2017

Study information

• Verified date: January 2017
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Intrauterine growth restriction refers to a fetus that has failed to get a specific measures by a gestational age. Asymmetric type of Intrauterine growth restriction is known by normal sized head with smaller abdomen.It is important to recognize the growth restricted fetuses, because these fetuses may have fetal or neonatal complications.

When blood flow is increased, the oxygen and nutrients will deliver good to the fetus. The role of low-dose aspirin therapy in management of intrauterine growth restriction is controversial. It has been used, in many studies, in prevention of intrauterine growth restriction especially in women at high risk of pre-eclampsia or obstetrical antiphospholipid syndrome.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: January 2017
• Est. primary completion date: January 2017
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 20 Years to 35 Years

Eligibility

Inclusion Criteria:

• The pregnant women

• 28-30 weeks

• Idiopathic asymmetrically intrauterine growth restriction

• Middle aged women (20-35 years)

• Women with abnormal umbilical artery Doppler flow indices ( > +2 standard deviation above mean for gestational age)

Exclusion Criteria:

• Women less than 20 and more than 35 years

• hypertensive or diabetic women

• any type of smoking

• multiple pregnancies

• amniotic fluid index <5 cm

• premature pre-labor rupture of membranes

• abnormal placenta

• any fetal congenital malformations.

• women had absent diastolic flow or reversed flow in umbilical artery at the time of recruitment.

Related Conditions & MeSH terms

• Fetal Growth Retardation
• Intrauterine Growth Restriction Asymmetrical

Intervention

Drug:
• Aspirin
This group were subjected to aspirin 75 mg once daily for 6 weeks.

Locations

Country	Name	City	State
Egypt	Women Health Hospital - Assiut university	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Estimated fetal weight		6 weeks
Secondary	Birth weight		6 weeks
Secondary	Changes in Doppler blood flow indices in umbilical artery		6 weeks