Inherited Susceptible Genes Among Epithelial Ovarian Cancer

Hereditary Breast and Ovarian Cancer Syndrome Clinical Trial

Official title:

Cohort Study on Characters and Distribution of Inherited Susceptible Genes Among Epithelial Ovarian Cancer Patients and Their Relatives in the North of China

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03015376
• Other study ID #: EOC-GENE
• Status: Recruiting
• Start date: January 2017
• Est. completion date: January 2019

Study information

• Verified date: November 2018
• Source: Peking Union Medical College Hospital
• Contact: Wu Ming, MD
• Phone: +86-13801224549
• Email: drwuming[@]sina.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Purpose: To investigate the prevalence of the germline mutations in the BRCA 1/2 and mismatch repair genes in patients with epithelial ovarian cancer (EOC) and their relatives, and related somatic mutations in tumor tissues in the northern part of china.

Patients and methods: A multicenter prospective study will be hold in the northern part of china form 2017. About 1000 female patients with epithelial ovarian cancer and their ralatives will be tested for germline mutations in the BRCA 1/2 and mismatch repair genes and related somatic mutations in tumor tissues, regardless of the family history.

Study type: Observational Official title: Prevalence study of germline mutations in susceptibility ovarian cancer genes in patients with epithelial ovarian cancer and somatic mutations in their tumor tissures in the northern part of china.

Enrollment: 1000

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1000
• Est. completion date: January 2019
• Est. primary completion date: January 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. epithelial ovarian cancer and their relatves

2. living in the north of Huaihe River in China

3. being Han Chinese

Exclusion Criteria:

1. non-epithelial ovarian cancer

2. without specific pathological diagnosis

3. non-Han Chinese

Related Conditions & MeSH terms

• Hereditary Breast and Ovarian Cancer Syndrome
• Neoplasms, Glandular and Epithelial
• Ovarian Neoplasm Epithelial
• Ovarian Neoplasms

Locations

Country	Name	City	State
China	Lei Li	Beijing	Beijing
China	Peking Union Medical College Hospital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Peking Union Medical College Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	herited gene mutations susceptible to epithelial ovarian cancer in patients and their relatives		two years