Myocardial Injury Clinical Trial
The purpose of this study was to evaluate the protective effect of dexmedetomidine on myocardial injury during liver transplantation
Liver transplantation surgery may lead to myocardial injury. Dexmedetomidine, a highly specific α2-adrenoeptor agonist, has sedative and analgesic properties without significant respiratory depression at the clinically approved dosage. Some investigations indicated that dexmedetomidine was able to protect the myocardium via improving the activity of Na+-K+-adenosine triphosphate enzyme and Ca2+-adenosine triphosphate, alleviating inflammation reaction and avoiding Ca2+ overload. However, the effect and the mechanism of dexmedetomidine on myocardial injury during liver transplantation remain unclear. ;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03940651 -
Cardiac and Renal Biomarkers in Arthroplasty Surgery
|
Phase 4 | |
| Completed |
NCT01688648 -
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
|
N/A | |
| Completed |
NCT04794062 -
Myocardial Injury and Quality of Life After COVID-19
|
||
| Recruiting |
NCT04750616 -
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
|
Phase 2 | |
| Recruiting |
NCT04615871 -
Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19
|
Phase 2 | |
| Withdrawn |
NCT04139655 -
Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study
|
N/A | |
| Completed |
NCT05691764 -
Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery
|
N/A | |
| Completed |
NCT04436016 -
PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
|
Phase 4 | |
| Completed |
NCT05748691 -
Switching From Cardiac Troponin I to T
|
||
| Completed |
NCT03338504 -
Determining the Mechanism of Myocardial Injury and Role of Coronary Disease in Type 2 Myocardial Infarction
|
||
| Completed |
NCT00007358 -
Dexamethasone Treatment for Congenital Heart Block (CHB) in Newborns With Lupus
|
N/A | |
| Recruiting |
NCT05714618 -
MR Evidence of Cardiac Inflammation Post-Stroke
|
||
| Recruiting |
NCT04624503 -
Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19
|
||
| Active, not recruiting |
NCT03339180 -
Cardiac Injury in Patients With Influenza
|
||
| Completed |
NCT03010839 -
Cardiopulmonary Protective Effects of Modified Remote Ischaemic Preconditioning in Mitral Valve Replacement Surgery
|
N/A | |
| Recruiting |
NCT04743765 -
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
|
N/A | |
| Enrolling by invitation |
NCT03253835 -
Cardiac Blood Flow Patterns Associated With Left Ventricular Myocardial Damage
|
||
| Completed |
NCT00817791 -
Preconditioning With Hyperbaric Oxygen in Cardiovascular Surgery
|
N/A | |
| Completed |
NCT04149314 -
The "Hypotension Prediction Index" in Patients Undergoing Lung Surgery
|
N/A | |
| Active, not recruiting |
NCT05462730 -
Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction
|
Phase 2 |