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Clinical Trial Summary

This study will enroll patients who have metastatic pancreatic cancer and have progressed on prior chemotherapy. Part 1 (dose escalation) participants will receive epacadostat/pembrolizumab/cyclophosphamide(CY)/GVAX pancreas vaccine followed by epacadostat/pembrolizumab/CRS-207, Part 1X (dose escalation) participants will receive epacadostat/pembrolizumab/CRS-207. Part 2X (dose expansion) participants will receive epacadostat/pembrolizumab/CRS-207. The primary objectives of this study are to determine the recommended dose of epacadostat in this combination and assess survival of subjects in both treatment groups.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03006302
Study type Interventional
Source Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Contact Susan Sartorius-Mergenthaler, R.N.
Phone 410-614-3644
Email [email protected]
Status Recruiting
Phase Phase 2
Start date January 23, 2018
Completion date February 2022

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