| Eligibility |
Inclusion Criteria:
1. Age: 18 -75, no limitation for ethnic and gender
2. Body Mass Index(BMI) < 35 kg/m2
3. Patients with nonalcoholic steatohepatitis (NASH) based on liver biopsy obtained
within 6 months before randomization. The histological evidence of NASH was defined as
Non - alcoholic fatty liver disease activity score(NAS)= 4 (according to Nonalcoholic
Steatohepatitis Clinical Research Network, NASH CRN) with a minimum 1 score for
steatosis, lobular inflammation, and hepatocyte ballooning respectively.
4. Fibrosis stage 0-3 according to nonalcoholic steatohepatitis clinical research
network(NASH CRN).
5. Without history of significant alcohol consumption for a period of more than 3 months
within 5 years (<10 g/day for female and < 20 g/day for male).
6. The lab test results should meet the requirements:
? Alanine aminotransferase (ALT) < 5 times of normal upper limit
? Creatinine (Cr)< normal upper limit
? Albumin (ALB)> 3.5g/L
? International normalized ratio(INR)= 0.8-1.3
? Fasting plasma glucose(FPG) < 126mg/dL(7mmol/L) and/or 2h postprandial plasma
glucose (PPG) < 200mg/dL(11.1mmol/L)and/ or HbA1C < 6.5 %
7. If a participant with hypertension, he/she was required a stable antihypertensive
drug(s) to keep blood pressure stable.(blood pressure < 140/90 mmHg) 3 months prior to
randomization.
8. If a participant using a statin or fibrate, he/she was required on a stable dose to
keep lipid stable (triglyceride(TG) < 1.7 mmol/L, total cholesterol (TC) < 5.72
mmol/L, LDL-c < 3.64 mmol/L) 3 months prior to randomization.
9. Women of childbearing potential: negative pregnancy test during screening or at
randomization or willingness to use an effective form of birth control during the
trial(at least include one barrier contraceptive method) and not breast feeding
10. Men must agree to use an effective form of birth control during the trial(at least
include one barrier contraceptive method)
11. All participants are needed to sign the informed consent form.
Exclusion Criteria:
1. Evidence of other form of acute or chronic liver disease. (Virus hepatitis, Hereditary
hemochromatosis, Hepatolenticular degeneration, Alcoholic liver disease, Drug-induced
hepatopathy).
2. History of diabetic mellitus or use of antidiabetic drugs.
3. Known heart failure of New York Heart Association class 2, 3, or 4.
4. Wear of cardiac pacemaker.
5. Hypothyroidism (TSH > 2 times of upper normal limit).
6. History of disease affecting drug absorption, distribution, metabolism (inflammatory
bowel disease, gastrointestinal surgery, chronic pancreatitis, gluten allergy,
vagotomy).
7. Use of anti-NASH drugs within 3 months before randomization (metformin,
thiazolidinediones, dipeptidyl peptidase-4 (DPP-4) inhibitor, glucagon-like
peptide-1(GLP-1), sodium glucose contransporter2(SGLT2), S-adenosylmethionine
-e(SAM-e), polyene phosphatidyl choline, glycyrrhizin, bicyclol, reduced glutathione,
betaine, fish oil, silymarin,oberbic acid/ursodeoxycholic acid (OCA/UDCA),
phosphodiesterase (PDE)-inhibitor, gemfibrozil, vitamin E, long term antibiotic (>1
week).
8. Positivity of antibody to Human Immunodeficiency Virus.
9. Inability to safely obtain liver biopsy.
10. Known intolerance to vitamin E
11. Inability to fill out diary card, to manage diet and exercise, poor compliance.
12. Dependence or abuse of alcohol and/or drugs.
13. Any other condition which in the opinion of investigator would impede compliance or
hinder completion of the study.
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