The Effects of Working Memory Training in Children With Attention-Deficit/Hyperactivity Disorder

Attention Deficit Disorder With Hyperactivity Clinical Trial

Official title:

The Effects of Working Memory Training in Children With Attention-Deficit/Hyperactivity Disorder

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02959528
• Other study ID #: 104-5308A3
• Status: Completed
• Phase: N/A
• First received: October 31, 2016
• Last updated: October 25, 2017
• Start date: October 2015
• Est. completion date: January 19, 2017

Study information

• Verified date: October 2017
• Source: Chang Gung Memorial Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Previous studies indicated that children with attention-deficit/hyperactivity disorder (ADHD) often suffer from deficits in executive function, such as attentional control, inhibition, and working memory. One of these executive functions, working memory, plays a critical role in academic performance and classroom behavior. Working memory is essential for performing complex cognitive tasks such as comprehension, learning, and reasoning. Several studies have shown that training of working memory has positive effects for ADHD and other cognitive disorder in children. However, transfer effects across studies appear to be variable and inconsistent. Event-related potentials can be a useful tool to gain insights into such mechanism. Therefore, the aim of the present study is to investigate both near and far transfer effects of N-back training in children with ADHD. In addition, the recording and analysis of event-related potentials will be adopted while children with ADHD perform the complex visuo-spatial and phonological working memory tasks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: January 19, 2017
• Est. primary completion date: November 25, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 8 Years to 10 Years

Eligibility

Inclusion Criteria:

• ADHD diagnosed according to criteria specified in Diagnostic and statistical manual of mental disorders (DSM-5)

• aged between 8 and 10 years

• intelligence quotient > 80 (based on Test of Nonverbal Intelligence-Third Edition)

• had normal or corrected-to-normal vision

• right-handed

Exclusion Criteria:

• diagnosis of clinically significant oppositional defiant disorder, Autistic Spectrum Disorders, Asperger's syndrome or depression

• history of seizures

Related Conditions & MeSH terms

• Attention Deficit Disorder With Hyperactivity
• Disease
• Hyperkinesis
• Psychophysiology

Intervention

Other:
• Working memory training
n-back training program
• perceptual training
visual-perceptual training program

Locations

Country	Name	City	State
Taiwan	Chang Gung University	Taoyuan City

Sponsors (1)

Lead Sponsor	Collaborator
Chang Gung Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Automated Working Memory Assessment	Visuospatial working memory change after intervention measured by Automated Working Memory Assessment	6 weeks
Secondary	Working memory index in Wechsler Intelligence Scale for Children-IV	Verbal working memory change after intervention measured by Working memory index in WISC-IV	6 weeks
Secondary	Event-related potentials	Event-related potentials are measured brain response on effects of working memory training	6 weeks