Delayed Encephalopathy After Carbon Monoxide Poisoning Clinical Trial
Official title:
Treatment of Human Cord Blood Mononuclear Cell for Delayed Encephalopathy After Carbon Monoxide Poisoning
The effects and safety of Human cord blood mononuclear cell for delayed encephalopathy after carbon monoxide poisoning
| Status | Recruiting |
| Enrollment | 60 |
| Est. completion date | December 2019 |
| Est. primary completion date | October 2018 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 35 Years to 60 Years |
| Eligibility |
Inclusion Criteria: - 35-60 years old. - No serious infection, chronic diseases, diabetes and tuberculosis. - Written informed consents were obtained from all subjects. - Symptomatic Delayed Encephalopathy After Carbon Monoxide Poisoning. Exclusion Criteria: - The heart, liver, kidney and other viscera serious organic disease. - Allergic constitution, clotting disorders, autoimmune diseases and tumors. - Pregnancy. - Moribund patient. - History of prior brain injury. - History of central nervous system disease. |
| Country | Name | City | State |
|---|---|---|---|
| China | Liaocheng city people's hospital | Liaocheng | Shandong |
| Lead Sponsor | Collaborator |
|---|---|
| Liaocheng People's Hospital |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Change From Baseline in Mini-Mental State Examination (MMSE) | Baseline, 4, 8, 12 and 24 weeks | ||
| Secondary | Chang from baseline in head CT | Baseline, 6 and 12 months | ||
| Secondary | Cerebrospinal levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-?,IL-17A,IL-8,IL-12p70,MIG,MCP-1(ng/ul) | Baseline, 1 and 2 months | ||
| Secondary | Serum levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-?,IL-17A,IL-8,IL-12p70,MIG,MCP-1(ng/ul) | Baseline,1 and 2 months | ||
| Secondary | Change From Baseline in Activities of Daily Living (ADL) | Baseline, 4, 8, 12 and 24 weeks |