Ventricular Tachycardia Clinical Trial
Official title:
Phase I/II Study of EP-guided Noninvasive Cardiac Radioablation for Treatment of Ventricular Tachycardia
Phase I/II Study of EP-guided Noninvasive Cardiac Radioablation (ENCORE) for Treatment of Ventricular Tachycardia
Patients with Ventricular Tachycardia (VT) who have failed standard therapy (medicines, invasive catheter ablation) have limited options, with one-year survival below 20%. Preclinical data demonstrate that single fraction stereotactic body radiotherapy (SBRT) to discrete portions of the heart is feasible and may result in a reduction or elimination of VT. The efficacy may be further improved when guided by cardiac electrophysiologic (EP) testing. In total, the mapping and ablation proposed for this EP-guided Noninvasive Cardiac Radioablation (ENCORE) is a rapid and totally non-invasive method. Overall safety and early efficacy of ENCORE have not been rigorously studied in a prospective trial to-date. The purpose of this phase I/II study is to demonstrate the short-term safety and preliminary efficacy of ENCORE for patients with life-threatening, treatment-refractory VT. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03453645 -
Modification of Rhythmic Risk Assessment by Ventricular Tachycardia Ablation
|
||
| Completed |
NCT05791032 -
Sub Chronic Evaluation for ATP With an Extravascular Placed ICD Lead (STEP ICD) Study
|
N/A | |
| Completed |
NCT05970120 -
A Study of Intracardiac Ultrasound With the NUVISION NAV Ultrasound Catheter
|
N/A | |
| Completed |
NCT04011631 -
Evaluation of the iD-SystemTM, One-Handed Disposable Internal Defibrillation System.
|
N/A | |
| Recruiting |
NCT03536052 -
Ablation at Virtual-hEart pRedicted Targets for VT
|
N/A | |
| Not yet recruiting |
NCT06063811 -
Ventricular Tachycardia Ablation in LVAD Patients
|
||
| Enrolling by invitation |
NCT02962076 -
Study of Cardiac PET/CT Imaging to Guide Ablation Treatment of Ventricular Tachycardia
|
Early Phase 1 | |
| Not yet recruiting |
NCT02784912 -
Biomarkers in Risk Stratification of Sustainted Ventricular Tachycardia or Electrical Storm After Ablation
|
N/A | |
| Completed |
NCT01791543 -
Intramural Needle Ablation for Ablation of Recurrent Ventricular Tachycardia
|
N/A | |
| Terminated |
NCT02891863 -
Low Energy Therapy to Convert Ventricular Tachycardias
|
Phase 0 | |
| Terminated |
NCT01546207 -
Stepwise Approach To sUbstrate Modification for Ventricular Tachycardia
|
N/A | |
| Completed |
NCT01294267 -
Percutaneous Hemodynamic Support With Impella 2.5 During Scar-related Ventricular Tachycardia Ablation
|
N/A | |
| Terminated |
NCT00383799 -
Iv Amiodarone Versus Iv Procainamide to Treat Haemodynamically Well Tolerated Ventricular Tachycardia
|
Phase 4 | |
| Completed |
NCT04884100 -
enHEART - Exploring Full Content of Optical Signals to Enhance Cardiac Arrhythmia Screening
|
N/A | |
| Completed |
NCT04642963 -
Stereotactic Management of Arrhythmia - Radiosurgery in Treatment of Ventricular Tachycardia
|
N/A | |
| Recruiting |
NCT05377216 -
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
|
Early Phase 1 | |
| Not yet recruiting |
NCT04990089 -
VIVO European Observational Registry
|
||
| Completed |
NCT04065893 -
Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
|
||
| Recruiting |
NCT03631303 -
Post-Extrasystolic Potentiation as a Predictor of Ventricular Arrhythmias
|
||
| Recruiting |
NCT03611465 -
Creation of a Pace-mapping Atlas on Healthy and Pathological Hearts
|
N/A |