Apoptotic Signal Pathways in Endometrial Hyperplasia Clinical Trial
Official title:
The Effect of Metformin and Medroxyprogesterone Acetate on Apoptotic Signaling Pathways in Wistar-Albino Rats With Induced Endometrial Hyperplasia
| Verified date | August 2016 |
| Source | Kayseri Education and Research Hospital |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | Turkey: Ethics Committee |
| Study type | Interventional |
The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.
| Status | Completed |
| Enrollment | 40 |
| Est. completion date | March 2015 |
| Est. primary completion date | March 2015 |
| Accepts healthy volunteers | No |
| Gender | Female |
| Age group | 8 Weeks to 10 Weeks |
| Eligibility |
Inclusion criteria: Forty-eight weeks old female Wistar-Albino rats, weighting between 180 and 260 g Exclusion criteria. We have no exclusion criteria because we examine drugs effects in the experimental rats |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| Turkey | Kayseri Training and Research Hospital | Kayseri |
| Lead Sponsor | Collaborator |
|---|---|
| Kayseri Education and Research Hospital |
Turkey,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Survivin Gene Expression Levels in Rat Uterine Tissue | 4 months | No | |
| Primary | Bcl-2 Gene Expression Levels in Rat Uterine Tissue | 4 months | No | |
| Primary | Bax Gene Expression Levels in Rat Uterine Tissue | 4 months | No | |
| Primary | c-Myc Gene Expression Levels in Rat Uterine Tissue | 4 months | No | |
| Primary | Caspase-9 Expression Levels in Rat Uterine Tissue | 4 months | No |