Demyelinating Autoimmune Diseases, CNS Clinical Trial
— EPICOfficial title:
Epigenetic Evaluation of HAT/HDAC Activity in Peripheral Blood Mononuclear Cells From Patients With Clinically Isolated Syndrome and Analysis of the Relationship With the Pathophysiology and Disease Activity
NCT number | NCT02862301 |
Other study ID # | API/2015/64 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | April 2016 |
Est. completion date | September 2020 |
The aim of the study is to compare the enzymatic activity of HATs and HDACs in peripheral blood mononuclear cell (PBMC) of patients with a clinically isolated syndrome (CIS group) and healthy controls (control group).
Status | Recruiting |
Enrollment | 55 |
Est. completion date | September 2020 |
Est. primary completion date | June 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Clinically isolated syndrome within the last 6 weeks (CIS group) - Healthy volunteer, free of any inflammatory disease (control group) - Patient able to understand the reason of the study - Signed informed consent Exclusion Criteria: - Pregnancy - Systemic corticosteroid therapy (>1mg/kg) - Immunosuppressive/immunomodulatory therapy (prior or ongoing) (CIS group) - Patient with ongoing infection (Control group) |
Country | Name | City | State |
---|---|---|---|
France | University Hospital | Besançon |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire de Besancon |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | HDAC/ HAT enzymatic activity (ratio) | day of inclusion |
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