Use of Mini-fluid Challenge for Fluid Responsiveness Prediction During One-lung Ventilation

Acute Circulatory Failure During One-lung Ventilation Surgery Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02858115
• Other study ID #: 2014-30
• Status: Completed
• Phase: N/A
• First received: August 3, 2016
• Last updated: August 5, 2016
• Start date: January 2014
• Est. completion date: August 2016

Study information

• Verified date: August 2016
• Source: Assistance Publique Hopitaux De Marseille
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Comité consultatif sur le traitement de l'information en matière de recherche dans le domaine de la santé
• Study type: Observational

Clinical Trial Summary

During thoracic surgery, an excessive use of fluid results in pulmonary complications. Dynamic fluid responsiveness predictors are not easily usable during one lung ventilation. The investigators hypothesized that the assessment by transesophageal echocardiography (TEE) of subaortic velocity time index (VTI) variation after 100 ml of crystalloid would predict fluid responsiveness in patients receiving one-lung ventilation.

This retrospective, observational, single center study was from January 2014 to December 2015. The investigators included 105 patients requiring one lung ventilation lung resection. The investigators analysed 39 patients presenting an acute circulatory failure. 100 ml of crystalloid was infused over 1-min. After an echocardiographic assessment at 1-min, remaining 400 ml were administered over 14-min Fluid responsiveness was defined as an increase in the VTI above 15% after infusion of 500 ml of crystalloid.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: August 2016
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Lung resection

• Acute circulatory failure

• One-lung ventilation

Exclusion Criteria:

• Sinusal rhythm

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

• Acute Circulatory Failure During One-lung Ventilation Surgery
• Shock

Intervention

Other:
• Fluid challenge
100 ml of crystalloid was infused over 1-min
• Trans-oesophageal echography
an echocardiographic assessment at 1-min,

Locations

Country	Name	City	State
France	hôpital Nord Assistance Publique Hôpitaux de Marseille	Marseille

Sponsors (1)

Lead Sponsor	Collaborator
Assistance Publique Hopitaux De Marseille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fluid responsiveness	increase of cardiac output of more than 15%	one day	No
Primary	Velocity time index	: Echographic assesment of cardiac output	one day	No
Secondary	Pulsed pressure variation	dynamic indice of fluid responsiveness	one day	No