Acute Endophthalmitis Post-operative Clinical Trial
— Targeted PCROfficial title:
Contribution of Fast Molecular Bacterial Identification by Real-time PCR in Managing of Postoperative Acute Endophthalmitis
Endophthalmitis is a serious eye infection of exogenous origin (post-operational,
post-traumatic) or endogenous origin (metastatic). This is a diagnostic and therapeutic
emergency.
Each patient suffering from endophthalmitis must have immediately an ocular sampling, an
intra ocular injection of antibiotics and a systemic antibiotic cover.
The etiological treatment will be adapted according to the infectious agent.
| Status | Recruiting |
| Enrollment | 150 |
| Est. completion date | August 2016 |
| Est. primary completion date | August 2016 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Subjects affiliated to the social security system - Signed informed consent documentation - Patients over 18 years - Male or female person - Patients hospitalized for diagnostic and therapeutic evaluation of a post-operative acute endophthalmitis, or within the context of a scheduled surgery with sampling of aqueous humour. - Has given his or her consent, having been provided with detailed informations regarding to intraocular sampling. Exclusion Criteria: - antibiotherapy via intravenous (< 8 days) for patients NON suffering from endophthalmitis (control group) - Patient's participation to the study refused - Patients under 18 years - Patients adults under guardianship or curatorship, or unable to express his/her consent. - Pregnant women - Breastfeeding women - Person deprived of liberty |
Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
| Country | Name | City | State |
|---|---|---|---|
| France | UniversityHospitalGrenoble | La Tronche |
| Lead Sponsor | Collaborator |
|---|---|
| University Hospital, Grenoble |
France,
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* Note: There are 58 references in all — Click here to view all references
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Visual acuteness | Clinical follow-up of patients | 2 minutes | No |
| Primary | Intraocular pressure | Clinical follow-up of patients | 5 minutes | No |
| Primary | Biomicroscopic exam with the slit lamp | State of anterior and posterior segment (back of the eye) | 3 minutes | No |