Postoperative; Dysfunction Following Cardiac Surgery Clinical Trial
Official title:
Continuous Monitoring of Cerebral Energy State During Cardiac Surgery - A Novel Approach Utilizing Intravenous Microdialysis
Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by microdialysis (MD) of the cerebral venous outflow reflects a derangement of global cerebral energy state during cardiopulmonary bypass.
Status | Completed |
Enrollment | 10 |
Est. completion date | May 2015 |
Est. primary completion date | April 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 60 Years and older |
Eligibility |
Inclusion criteria: - Elective CABG on CPB Exclusion criteria: - Acute patients or reoperations - Patients with epidural catheter - Previous stroke - Stenotic carotids - Ejection fraction (EF) < 50 % - Estimated per operative risk > 5% |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
Denmark | Odense University Hospital | Odense | Fyn |
Lead Sponsor | Collaborator |
---|---|
Odense University Hospital |
Denmark,
Ahonen J, Salmenperä M. Brain injury after adult cardiac surgery. Acta Anaesthesiol Scand. 2004 Jan;48(1):4-19. Review. — View Citation
McDonagh DL, Berger M, Mathew JP, Graffagnino C, Milano CA, Newman MF. Neurological complications of cardiac surgery. Lancet Neurol. 2014 May;13(5):490-502. doi: 10.1016/S1474-4422(14)70004-3. Epub 2014 Apr 2. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Extracerebral microdialysis parameters | Does the LP ratio of cerebral venous blood increase significantly during CPB indicating compromised cerebral oxidative metabolism.The analyses included the variables routinely monitored during intracerebral microdialysis: glucose, pyruvate, lactate, glutamate, glycerol and lactate to pyruvate ratio. | MD parameters were measured intraoperatively and for two hours postoperatively | No |
Secondary | Mini mental state examination (MMSE) | Patients were assessed preoperatively and postoperatively day two after surgery | Neurological complications with in 2 days after surgery | No |
Secondary | Near-infrared spectroscopy (NIRS) | Right and left frontal rSO2 values were recorded simultaneously pre- and intraoperatively and for two hours postoperatively. Cerebral desaturation was defined as a decrease in the relative rSO2 value of 20 % compared with the individual pre-induction baseline value | one day | No |
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