Breath Volatile Organic Compounds Patterns of Lung Transplant Patients With Chronic Lung Allograft Dysfunction

Chronic Lung Allograft Dysfunction (CLAD) Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02836938
• Other study ID #: TXVOC
• Status: Completed
• Phase: N/A
• First received: July 5, 2016
• Last updated: February 13, 2017
• Start date: June 2016
• Est. completion date: December 2016

Study information

• Verified date: February 2017
• Source: Fraunhofer-Institute of Toxicology and Experimental Medicine
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

It's the aim of this study to clarify, whether the non-invasive assessment of breath can serve as a novel clinical tool to assist in the diagnosis of CLAD. If different stages of BOS can be discriminated by the level of certain VOCs than there would also be a potential to actually predict the development at an early stage and would enable an earlier intervention.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 75
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Outpatient bilateral lung transplant recipients including combined transplants

Exclusion Criteria:

• Active Smoking Oxygen therapy Infection with multi or pan-resistant bacteria

Related Conditions & MeSH terms

• Chronic Lung Allograft Dysfunction (CLAD)

Intervention

Other:
• Collection of exhaled breath volatile organic compounds

Locations

Country	Name	City	State
Germany	Hannover Medical School	Hannover

Sponsors (2)

Lead Sponsor	Collaborator
Prof. Dr. Jens Hohlfeld	Hannover Medical School

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Concentration of exhaled breath volatile organic compounds		one sample will be collected between 6 month and 20 years after lung transplantation