Primary Central Nervous System Lymphoma Clinical Trial
Official title:
Therapeutic Effects of R-IDARAM and Intrathecal Immunochemotherapy on Elderly Patients With Primary CNS Lymphoma
This study suggests that R-IDARAM combined with intrathecal immunochemotherapy may be high effective in elderly patients with primary central nervous system lymphoma (PCNSL).
The investigators will evaluate response rate, progression free survival (PFS), overall survival (OS), and toxicity in elderly patients with primary central nervous system lymphoma (PCNSL) after systemic and intrathecal immunochemotherapy with deferred radiotherapy. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04083066 -
Open Randomized Prospective Clinical Study of R-FPD Versus R-MAD Regimen in the Treatment of Primary Central Nervous System Lymphoma
|
Phase 4 | |
Active, not recruiting |
NCT02313389 -
Maintenance Treatment Versus Observation in Elderly Patients With PCNS Lymphoma
|
Phase 3 | |
Recruiting |
NCT02657785 -
Treatment of PCNSL With R-IDARAM and Intrathecal Immunochemotherapy
|
Phase 2/Phase 3 | |
Recruiting |
NCT06445257 -
A Clinical Study Evaluating the Safety and Efficacy of ZRMT Regimen in the Treatment of PCNSL
|
N/A | |
Recruiting |
NCT05135858 -
Dose Dense Re-challenge of High Dose Methotrexate With Glucarpidase for Relapsed Primary Central Nervous System Lymphoma
|
Phase 1 | |
Completed |
NCT01421524 -
Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma
|
Phase 1 | |
Active, not recruiting |
NCT00863460 -
Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue for Primary Central Nervous System Lymphoma in Young Patients
|
Phase 2 | |
Active, not recruiting |
NCT05036577 -
A Dose-escalating Pilot Study of Orelabrutinib for Newly-diagnosed PCNSL
|
Phase 1 | |
Recruiting |
NCT04514393 -
Ibrutinib With Methotrexate and Temozolomide for Patients With Newly Diagnosed Primary CNS Lymphoma
|
Phase 2 | |
Not yet recruiting |
NCT04066920 -
IBER Salvage Treatment Followed by Ibrutinib Maintenance for Relapsed or Refractory PCNSL
|
Phase 2 | |
Recruiting |
NCT03733327 -
BUCYE Conditioning Regimen for PCNSL Undergoing Auto-HSCT
|
Phase 2/Phase 3 | |
Recruiting |
NCT00455286 -
a Phase II Study in Primary Central Nervous System Lymphoma
|
Phase 2 | |
Completed |
NCT02301364 -
Buparlisib (BKM120) In Patients With Recurrent/Refractory Primary Central Nervous System Lymphoma (PCNSL) and Recurrent/Refractory Secondary Central Nervous System Lymphoma (SCNSL)
|
Phase 2 | |
Completed |
NCT00112593 -
Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer
|
N/A | |
Completed |
NCT02669511 -
PQR309 in Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma
|
Phase 2 | |
Not yet recruiting |
NCT04457869 -
A Study of F520 in Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) or Secondary Central Nervous System Lymphoma (SCNSL)
|
Phase 2 | |
Recruiting |
NCT02655744 -
Prospective Neurobehavioral Outcomes Follow-up in Primary CNS Lymphoma Patients Treated With Cranial Radiotherapy Combined With or Without MTX-based Chemotherapy According to the Multidisciplinary Treatment Guidelines Implemented at a Single Institute
|
||
Recruiting |
NCT02399189 -
MT-R Followed by Autologous Stem Cells Transplantation in Newly-diagnosed Primary Central Nervous System Lymphoma
|
Phase 2 | |
Recruiting |
NCT04831658 -
A Prospective Clinical Study of BTK Inhibitor, PD-1 and Formustine in the First-line Treatment of Primary Central Nervous System Lymphoma
|
Phase 1/Phase 2 | |
Recruiting |
NCT04899427 -
Phase II Study of Orelabrutinib Combined With PD-1 Inhibitor in Relapsed/Refractory Primary Central Nervous System Lymphoma
|
Phase 2 |