Systemic Inflammatory Response Syndrome Clinical Trial
Official title:
The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism
Verified date | June 2016 |
Source | Beijing Chao Yang Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | China: Ministry of Health |
Study type | Observational |
Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.
Status | Active, not recruiting |
Enrollment | 300 |
Est. completion date | April 2017 |
Est. primary completion date | April 2017 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 14 Years to 80 Years |
Eligibility |
Inclusion Criteria: - oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure - mechanical ventilation time over than 48 hours - Glasgow score greater more than or equal to 13 points Exclusion Criteria: - Aged less than 14 years or more than 80 years old - patients with neuromuscular disease - pure heart failure pulmonary edema patients - patients with tracheotomy |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Beijing Chao Yang Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The relationship between mechanical ventilation of ventilator and inflammatory response | Through the study of mechanical ventilation weaning success and failure of patients with respiratory physiological indicators, blood, urine related inflammatory indicators, analysis of the relationship between inflammatory response and mechanical ventilation weaning.The test indicators include C- reactive protein, tumor necrosis factor and some interleukin for related. | January 2014 to December 2016 | Yes |
Secondary | The relationship between diaphragm movement function and weaning from mechanical ventilation | To study the relationship between the inflammatory response and the contractile function of diaphragm, which is helpful to judge the effect of inflammatory factors on the evacuation of mechanical ventilation. | January 2016 to December 2017 | Yes |
Secondary | the output of CO2 | January 2016 to December 2017 | Yes |
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