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Biological Collection and Registry of Patients Who Will Have a TAVR (Transcatheter Aortic Valve Replacement) Intervention — BIO TAVI  

Transcatheter Aortic Valve Replacement Clinical Trial

Clinical Trial Summary

A sample of plasma and whole blood will be obtained at 4 time points (pre-procedural, early post-procedural, at hospital discharge and during an eventual visite at 3 or 6 months post-procedural). Test for platelet reactivity (LTA, light transmittance aggregometry and Elisa PRI, Platelet reactivity index), multimeric VWF (von Willebrand factor) and blood level of NET: neutrophil extracellular traps(flow cytometry and ELISA) analyses will be performed at the time of blood sampling. Aliquots of plasma will be stored and frozen for further analyses

Clinical Trial Description

There are two major objectives:

- To correlate changes in VWF, platelet reactivity and blood level of NET after TAVR with clinical outcomes

- To correlate changes in VWF, platelet reactivity and blood level of NET with antithrombotic regimens after TAVR (direct anticoagulants apixaban versus standard of care, ie Vitamin K antagonist or antiplatelet therapy). ;

Study Design

Related Conditions & MeSH terms

  • Transcatheter Aortic Valve Replacement
Clinical Trial Details
NCT number NCT02812953
Study type Observational [Patient Registry]
Source Action, France
Contact Jean Philippe COLLET, MD, PhD
Phone +33142162962
Email jean-philippe.collet@aphp.fr
Status Recruiting
Phase
Start date May 2016
Completion date December 2022
View Details
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