General Glucocorticoid Resistance Clinical Trial
— MUTA-GROfficial title:
Prevalence of Mutations of Glucocorticoid Receptors in Bilateral Adrenal Hyperplasia
| NCT number | NCT02810496 |
| Other study ID # | PN11010 |
| Secondary ID | |
| Status | Recruiting |
| Phase | N/A |
| First received | June 16, 2016 |
| Last updated | June 20, 2016 |
| Start date | April 2012 |
As the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously described. To validate this hypothesis, it was decided to study 150 multicenter consecutive patients, presenting with incidentally discovered bilateral adrenal masses without clinical signs of Cushing's disease. In all these patients GR gene will be studied, mutations will be detected and described, functional disturbance will be tested. Usual polymorphisms will be described. Correlation between clinical signs, hormonal and morphological abnormalities and presence or absence of GR mutations will be searched.
| Status | Recruiting |
| Enrollment | 150 |
| Est. completion date | |
| Est. primary completion date | December 2016 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - patients more than 18 years of age - patients with bilateral adrenal masses Exclusion Criteria: - Refusing to participate in the study - Protected by law - Have obvious signs of Cushing's syndrome - No progressive neoplastic disease |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Country | Name | City | State |
|---|---|---|---|
| France | Chu Reims | France | Reims |
| Lead Sponsor | Collaborator |
|---|---|
| CHU de Reims |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | frequency of mutations | DAY 0 | No |