Pancreatic Ductal Adenocarcinoma (PDAC) Clinical Trial
Official title:
Perioperative FOLFIRINOX for Patients With Resectable Pancreatic Adenocarcinoma: A Pilot Study
The purpose of this study is to see whether it is possible to give 8 doses of a combination of chemotherapy called FOLFIRINOX before surgery in subjects whose pancreas cancer can be removed with surgery.
Primary Objective: To evaluate the percentage of pancreatic cancer patients able to complete
the full 4 months of preoperative chemotherapy and undergo a resection.
Secondary Objectives
- To assess the percentage of patients able to complete all therapy, including
preoperative chemotherapy, surgery, and postoperative therapy.
- To assess treatment-related toxicity during preoperative therapy
- To assess intra-operative and post-operative complications
- To assess the histopathologic (R0/R1) resection rate after preoperative therapy
- To determine disease free survival (DFS) for patients who undergo resection.
- To determine progression free survival (PFS) for all patients
- To determine overall survival (OS) from the date of first treatment
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