Other Clinical Trial - Comparing Pain Relief Between Exparel® Injection

Clinical Trial Summary

The goal of this research project is to evaluate the effectiveness of a novel treatment to control pain after Total Knee Arthroplasty (TKA). The proposed approach to manage pain and eliminate risks associated with catheters is the use of Exparel injection into the joint at the time of surgery.

Clinical Trial Description

n/a

Study Design

Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Related Conditions & MeSH terms

Osteoarthritis: Joint Replacement Surgery

See also
	Status	Clinical Trial	Phase
	Withdrawn	`NCT03912116` - Amniotic Umbilical Cord Particulate During Total Knee Arthroplasty	N/A

See also

Status

Clinical Trial

Phase

Withdrawn

NCT03912116 - Amniotic Umbilical Cord Particulate During Total Knee Arthroplasty

N/A

Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.

Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.

Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

NCT number	NCT02739230
Study type	Interventional
Source	Rothman Institute Orthopaedics
Contact
Status	Completed
Phase	N/A
Start date	December 2013

Comparing Pain Relief Between Exparel® Injection vs. On-Q Catheter as the Postsurgical Analgesia Following Total Knee Arthroplasty (TKA)

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms