Non ST-elevation Myocardial Infarction Clinical Trial
Official title:
Impact of Time to Coronary Angiography on Survival for NSTEMI: an Observation Study Using a Nationwide Registry
This study aims to investigate the extent to which the time to angiography impacts on survival in patients hospitalised with NSTEMI.
The use of an invasive strategy for the management of NSTEMI according to estimated risk of
6 month mortality is recommended by international guidelines. NSTEMI appropriate for
coronary angiography (and percutaneous intervention) have better outcomes compare with
NSTEMI who are medically managed. Whilst the national and international guidelines recommend
that the timing of (in-hospital) coronary angiography (<24, 24-72, 72-96 and <96 hours) is
based upon estimated clinical risk (using the GRACE risk score) there is scientific and
clinical uncertainty as to the incremental benefit that more urgent invasive treatments
strategies have over and above that of delayed strategies. Moreover, the investigators
recent research has shown that in the UK, may NSTEMI (eligible) for coronary angiography
fail to achieve care according to the recommended time thresholds, and this is associated
with potentially avoidable premature death.
This study aims to investigate the extent to which the time to angiography impacts on
survival in patients hospitalised with NSTEMI. It will characterise patients according to
their estimated risk of death, their time to angiography, and associated outcomes. The
investigators anticipate that this observational study will provide Level B evidence for the
benefits of the timing of an invasive strategy according to the GRACE risk score. The
investigators are aware that the NICE guidelines for the management of acute chest pain are
to be updated in 2016.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02436187 -
Guideline Recommended Care and Excess Mortality for Non ST-elevation Myocardial Infarction : A National Cohort Study
|
||
| Completed |
NCT02600962 -
Impact of Initial Diagnosis on Mortality for Patients Hospitalised With Acute Myocardial Infarction
|
N/A | |
| Completed |
NCT02406248 -
Brilinta Taiwan Post Approval Safety Study
|
Phase 4 |