Gastrointestinal Subepithelial Tumors Clinical Trial
Non-erosive reflux disease (NERD) patients used to be less responsive to proton pump
inhibitor (PPI)s as compared with patients with erosive esophagitis. The aim of this study is
to objectively evaluate the effect of a new PPI, ilaprazole in NERD for adjusting the focus
of symptom score, histopathologic findings and inflammatory biomarker.
A prospective study performed at single hospital enrolled 20 patients who were diagnosed
clinically as NERD. Patients underwent EGD, a 24hr-combined multichannel intraluminal
impedance and pH esophageal monitoring (MII-pH) and were treated with ilaprazole 20mg once
daily for 4 weeks. Biopsies were obtained from 3cm above the EG junction before and after
treatment. GERD Q questionnaire, histologic findings (basal cell hyperplasia, papillary
elongation, dilated intercellular spaces, intraepithelial eosinophils and intraepithelial T
lymphocyte) and inflammatory biomarkers (TNF-α, IL-8, IL-1β, TRPV1 and MCP-1) will be
accessed.
n/a
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|---|---|---|---|
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