Hereditary Breast and Ovarian Cancer Syndrome Clinical Trial
Official title:
Evaluation of the Circulating Concentration of Olfactomédine 4 (OLFM4) in Women With a BRCA1 or 2 Gene Mutation or at High Risk of Developing Breast Cancer, According to the Imaging
Does the olfactomédine provide an help to limit the number of false positives in the overall imaging balance and limit the number of unnecessary biopsies?
About 5% of breast cancers are associated with the presence of a constitutional genetic
alteration. Two genes are being studied: BRCA1 and BRCA2.
The national program for breast cancer screening target women 50 to 74 years but does not
include women with significant risk factors. However in identifiable risk situations, breast
cancer incidence is increased: and it affects 1 in 4 women with certain risk histological
lesions and more than 1 in 2 women carrying a mutation in the BRCA1 or BRCA2 gene.
Studies have shown that the olfactomédine 4 (OLFM4) is highly overexpressed in tumors
compared to healthy tissue. The OLFM4 might therefore be a marker for early detection of
breast cancer. We wish to determine the positive predictive value of OLFM4 seric dosing of
patients at risk with respect to imaging.
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