Postoperative Cognitive Dysfunction Clinical Trial
Official title:
Optimizing Postoperative Cognition the Elderly
This study will recruit surgical patients more than 65 years old. Patients who participate will wear a sticker on their forehead during surgery which monitors their brain waves (electroencephalogram, EEG) and participate in memory testing before and after surgery. Brain wave patterns will be compared between patients who have problems with memory and thinking after surgery and those who do not. The hypothesis is that there will be characteristic brain wave patients for who will go on to have problems with memory and thinking after surgery.
Eligible patients will be identified through the computerized scheduling system at the Icahn
School of Medicine at Mount Sinai. After informed consent, patients will complete cognitive
and tests at least one but not more than 30 days prior to surgery. In the recovery room the
Post Anesthesia Recovery Scale (PQRS), and CAM-ICU delirium screening will be administered.
Immediate recovery will be recorded using the Postoperative Recovery Scale (PQRS) on
postoperative day 1 and 3, and 1 week.
Longterm functional recovery will be measured with the Alzheimer's Disease Research Center
(ADRC) Instrumental Activities for Daily Living (IADL-24). Postsurgical complications will be
recorded including unplanned ICU admissions, postoperative myocardial infarction and stroke
(risk less than 1 % in most cases), wound infection and reoperation. The full cognitive and
functional battery will be repeated at 3 months and 1 year after surgery.
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