Physical Exercise Behavior (Liking/Aversion) Clinical Trial
— EXEBRAINOfficial title:
Molecular and Functional Neurobiology of Physical Exercise
NCT number | NCT02615756 |
Other study ID # | 19/180/2013 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | April 2013 |
Est. completion date | June 2018 |
Verified date | March 2021 |
Source | Turku University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.
Status | Completed |
Enrollment | 24 |
Est. completion date | June 2018 |
Est. primary completion date | June 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: 1. Native Finnish speaker 2. Age > 18 years 3. Western Caucasian origin Exclusion Criteria: 1. Age < 18 or > 65 2. History or current mental disorder 3. BMI > 27 kg/m2 4. Use of drugs that influence the central nervous system, including nicotine 5. Poor compliance 6. Any chronic medical defect or injury which hinder or interfere everyday life 7. Eating disorder 8. Current or past excessive use of alcohol or substance abuse 9. Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv 10. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results 11. Presence of any ferromagnetic objects that would make MR imaging contraindicated |
Country | Name | City | State |
---|---|---|---|
Finland | Turku PET Centre | Turku |
Lead Sponsor | Collaborator |
---|---|
Turku University Hospital | Academy of Finland, Juho Vainio Foundation, Novo Nordisk A/S, University of Turku |
Finland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Binding of [11C]carfentanil in brain confirmed by positron emission tomography | Change in binding of [11C]carfentanil in baseline and 20 min after physical exercise completion | Baseline and 20 min after physical exercise completion |