Associations Between Periodontitis and Autoimmune Antibodies in Rheumatoid Arthritis Disease

Periodontitis, Rheumatoid Arthritis, Autoimmunity, Clinical Trial

Official title:

Associations Between Periodontitis and Autoimmune Antibodies in Rheumatoid Arthritis Disease

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT02577679
• Other study ID #: 201503116RINA
• Status: Active, not recruiting
• Phase: N/A
• First received: September 23, 2015
• Last updated: October 14, 2015
• Start date: June 2015
• Est. completion date: November 2015

Study information

• Verified date: October 2015
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Ministry of Health and Welfare
• Study type: Observational

Clinical Trial Summary

The aim of this case control study is to explore the possible association between periodontal destruction and serum anti-CCP antibodies in RA patients and healthy subjects.

Description:

In patients with RA, the anti-CCP antibody titer seems positively correlated to their periodontal destruction and disease activity in comparison with healthy subjects.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 47
• Est. completion date: November 2015
• Est. primary completion date: September 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 60 Years to 80 Years

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Autoimmune Diseases
• Periodontitis
• Periodontitis, Rheumatoid Arthritis, Autoimmunity,

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Serum level of anti-cyclic citrullinated peptide/protein antibody	Lower then 7 Unit/milliliter: negative 7-10 Unit/milliliter: weak positive Higher then 10 Unit/milliliter: positive	Base line	Yes
Primary	Periodontal pocket depth and clinical attachment level	Lower then 4 millimeter: normal Higher then 4 millimeter: diseased/previously diseased	Baseline	No
Secondary	Serum level of tumor necrotic factor alpha	Recorded in picogram per milliliter	Baseline	Yes
Secondary	Serum level of anti-mutated citrullinated vimentin	Recorded in Unit per milliliter	Baseline	Yes
Secondary	Serum level of interleukin 6	Recorded in picogram per milliliter	Baseline	Yes
Secondary	Serum level of interleukin 17	Recorded in picogram per milliliter	Baseline	Yes