cAMP Signaling and Muscle Adaptations

Muscle Hypertrophy in Healthy Young Men Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02557581
• Other study ID #: TUD
• Status: Recruiting
• Phase: N/A
• First received: September 13, 2015
• Last updated: October 25, 2017
• Start date: July 2015
• Est. completion date: October 2017

Study information

• Verified date: October 2017
• Source: University of Copenhagen
• Contact: Morten Hostrup, PhD
• Phone: +4524474785
• Email: mortenhostrup[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 72
• Est. completion date: October 2017
• Est. primary completion date: June 30, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• healthy young men

• 18-35 years of age

• Informed consent

• Active 2-5 hours of training pr. week

• Maximal oxygen uptake (ml/min/kg) of 40-60

• Lean body mass of 55-65 kg / Lean mass index 14-22 kg/m2

Exclusion Criteria:

• Smoker

• Allergy towards study drugs

• Chronic disease

Related Conditions & MeSH terms

• Hypertrophy
• Muscle Hypertrophy in Healthy Young Men

Intervention

Other:
• No training

• Endurance training

• Resistance Training

Drug:
• Terbutaline

• Clenbuterol

• Placebo

Locations

Country	Name	City	State
Denmark	Bispebjerg University Hospital	Copenhagen
Denmark	Department of Nutrition, Exercise and Sports	Copenhagen

Sponsors (1)

Lead Sponsor	Collaborator
University of Copenhagen

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle hypertrophy (lean body mass in Kilograms)	Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)	2 days
Secondary	Energy turnover (ml/min or mmol/kg dry weight muscle)	Pulmonary gas exchange and lactate and glycogen will be measured in muscle biopsies obtained before and after intense exercise	1 day