Mechanical Ventilation Complication Clinical Trial
Official title:
Perioperative Pulmonary Recruitment and Postoperative Monitoring of Integrated Pulmonary Index in Off-pump Coronary Bypass Grafting
This study evaluates the influence of alveolar recruitment maneuver, protocolized liberation from respiratory support and monitoring of Integrated Pulmonary Index on the duration of the mechanical ventilation and the number of pulmonary complications in the early postoperative period after cardiac surgery.
The outcome of elective off-pump coronary artery bypass grafting (OPCAB) can be
significantly compromised due to early postoperative pulmonary complications. The risk of
pulmonary complications including acute respiratory distress syndrome (ARDS), atelectases,
and early ventilator-associated pneumonia remains inappropriate. Therefore, the maneuvers
improving pulmonary aeration and the early restoration of spontaneous breathing activity can
be of clinical value. Protocol-driven liberation from mechanical ventilation (CMV) can
decrease the duration of CMV as well as the number of pulmonary complications.
INTELLiVENT-Assisted spontaneous ventilation (INTELLiVENT-ASV) is a new approach, that may
be as effective as conventional protocol-driven liberation from CMV.
In parallel, the thorough postoperative monitoring of pulmonary function during both
postoperative mechanical ventilation and spontaneous breathing is also of a great value. One
of the novel approaches to respiratory monitoring is Integrated Pulmonary Index (IPI). The
Integrated Pulmonary Index merges four vital parameters including end-tidal carbon dioxide
(EtCO2), respiratory rate, pulse rate, and oxygen saturation (SpO2) measured by capnography
and pulse oximetry into a single index value utilizing fuzzy logic model .
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)
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