Familial Hypercholesterolemia - Heterozygous Clinical Trial
Official title:
MYOCARDIAL SILENT INFARCTIONS AND FIBROSIS IN FAMILIAL HYPERCHOLESTEROLEMIA
Patients with familial hypercholesterolemia (FH) at high cardiovascular risk may suffer from
silent micro-infarctions (MI) before clinical coronary heart disease manifestations because
of the lifetime exposure to elevated serum LDL-cholesterol levels.
The study aims to demonstrate the higher prevalence of silent myocardial infarction in a
population of asymptomatic patients with familial hypercholesterolemia at high
cardiovascular risk in comparison to control patients using Cardiac Magnetic Resonance
sequences of delayed gadolinium enhancement.
To demonstrate the higher prevalence of silent myocardial infarction in a population of
asymptomatic patients with familial hypercholesterolemia at high cardiovascular risk in
comparison to control patients, the protocol is the following:
- to enroll 75 patients with familial hypercholesterolemia (FH)
- to enroll 35 subjects without FH (control group)
- for each subject, to collect data from his medical file (blood test results) and to
perform a cardiac and aortic MRI in order to evaluate the micro-infarction proportion.
The study will be performed according to GCPs and with respect with french laws.
;
Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03501875 -
Study of Coronary Calcification in Subjects With Autosomal Dominant Familial Hypercholesterolemia Heterozygous
|
N/A | |
| Recruiting |
NCT04370899 -
Early Detection of Familial Hypercholesterolemia in Children
|
||
| Recruiting |
NCT04656028 -
Genetic Testing and Motivational Counseling for FH
|
N/A | |
| Active, not recruiting |
NCT04652726 -
Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Heterozygous Familial Hypercholesterolemia
|
Phase 3 | |
| Recruiting |
NCT05218005 -
Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia
|
N/A |