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Efficacy of Lifestyle Intervention in BRCA1/2 Mutation Carriers — LIBRE-2  

Hereditary Breast and Ovarian Cancer Clinical Trial

Official title:
Prospective Randomized Multicenter Trial to Assess the Efficacy of a Structured Physical Exercise Training and Mediterranean Diet in Women With BRCA1/2 Mutations

Clinical Trial Summary

The hypothesis of this 3 year, prospective randomized multicenter efficacy trial is that a structured life-style intervention program with exercise training and mediterranean diet is effective regarding increased adherence to a mediterranean diet, reduction of body mass index, and increase of physical fitness.

Clinical Trial Description

BRCA1/2 mutation carriers have a considerably increased risk to develop breast and ovarian cancer during their lifetime. There is evidence from the literature that for sporadic breast cancer disease risk and the course of disease can be significantly influenced by physical activity, nutrition and weight. The hypothesis of this 3 year, prospective randomized multicenter efficacy trial is that a structured life-style intervention program with exercise training and mediterranean diet is effective regarding increased adherence to a mediterranean diet, reduction of body mass index, and increase of physical fitness. ;

Study Design

Related Conditions & MeSH terms

  • Hereditary Breast and Ovarian Cancer
  • Hereditary Breast and Ovarian Cancer Syndrome
  • Ovarian Neoplasms
Clinical Trial Details
NCT number NCT02516540
Study type Interventional
Source Technical University of Munich
Contact Marion Kiechle, Prof. Dr.
Phone +49 89 4140 2420
Email marion.kiechle@tum.de
Status Recruiting
Phase N/A
Start date March 2015
Completion date March 2025
View Details
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