Clinical Stage IV Cutaneous Melanoma AJCC v8 Clinical Trial
Official title:
A Phase III Randomized Trial Comparing Physician/Patient Choice of Either High Dose Interferon or Ipilimumab to MK-3475 (Pembrolizumab) in Patients With High Risk Resected Melanoma
Verified date | February 2024 |
Source | National Cancer Institute (NCI) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This randomized phase III trial studies how well pembrolizumab works compared with the current standard of care, physician/patient choice of either high-dose recombinant interferon alfa-2B or ipilimumab, in treating patients with stage III-IV melanoma that has been removed by surgery but is likely to come back or spread. High-dose recombinant interferon alfa-2B may help shrink or slow the growth of melanoma. Immunotherapy with monoclonal antibodies, such as ipilimumab and pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether pembrolizumab is more effective than the current standard of care in treating patients with melanoma.
Status | Active, not recruiting |
Enrollment | 1345 |
Est. completion date | January 23, 2025 |
Est. primary completion date | September 15, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - STEP 1 REGISTRATION: - Patients must have completely resected melanoma of cutaneous origin or of unknown primary in order to be eligible for this study; patients must be classified as stage IIIA (N2a), IIIB, IIIC, or stage IV melanoma; patients with non-ulcerated T1b N1a disease are not eligible; patients with melanoma of mucosal or other non-cutaneous origin are eligible; patients with melanoma of ocular origin are not eligible; patients with a history of brain metastases are ineligible - Patients are eligible for this trial either at initial presentation of their melanoma or at the time of the first detected nodal, satellite/in-transit, distant metastases, or recurrent disease in prior lymphadenectomy basin or distant site; nodal, satellite/in-transit metastasis, distant metastases or disease in a prior complete lymphadenectomy basin must have been confirmed histologically by hematoxylin and eosin (H & E) stained slides - Patients with multiple regional nodal basin involvement are eligible; gross or microscopic extracapsular nodal extension is permitted - Patients at initial presentation of melanoma must undergo an adequate wide excision of the primary lesion, if present; patients with previously diagnosed melanoma must have had all current disease resected with pathologically negative margins and must have no evidence of disease at the primary site or must undergo re-resection of the primary site; a full lymphadenectomy meeting the criteria outlined is required for all node-positive patients including those with positive sentinel nodes; patients with recurrent disease who have had a prior complete lymphadenectomy fulfill this requirement as long as all recurrent disease has been resected; for all patients, all disease must have been resected with negative pathological margins and no clinical, radiologic, or pathological evidence of any incompletely resected melanoma; patients must be registered within 98 days of the last surgery performed to render the patient free of disease - Patients must have available and be willing to submit a minimum of five unstained slides from primary, lymph node, or metastatic site to determine PD-L1 expression; the tumor tissue must be adequate for PD-L1 testing (defined as >= 100 tumor cells as confirmed by the treating institution's local pathologist); this must be documented by having a pathologist sign the S1404 Local Pathology Review form prior to step 1 registration; the specimens may come from an archived block but must be submitted within 20 days from cutting the slides - Patients must be offered the opportunity to participate in specimen banking as outlined - Patients must be willing to have blood draws for PK/ADA analysis as outlined, should the patient be randomized to the MK-3475 arm - Patients may have received prior radiation therapy, including after the surgical resection; all adverse events associated with prior surgery and radiation therapy must have resolved to =< grade 1 prior to registration - Patients must not have received neoadjuvant treatment for their melanoma; patients must not have had prior immunotherapy including, but not limited to ipilimumab, interferon alfa-2b, high dose IL-2, pegylated (PEG)-IFN, anti-PD-1, anti-PD-L1 intra-tumoral, or vaccine therapies; patients must not be planning to receive any of the prohibited therapies during the screening or treatment phases of the study - Patients must not be planning to receive concomitant other biologic therapy, radiation therapy, hormonal therapy, other chemotherapy, surgery or other therapy after step 2 registration - All patients must have disease-free status documented by a complete physical examination and imaging studies within 42 days prior to registration; imaging studies must include a total body positron emission tomography (PET)-computed tomography (CT) scan that is of diagnostic quality (with or without brain) or a CT of the chest, abdomen and pelvis; for patients with melanoma arising from the head and neck, dedicated neck imaging (CT with IV contrast or PET-CT through the region) is required; if the patient has had unknown primary with disease in the axilla, neck imaging is required to assure region is clear of cancer; CT imaging should be done with intravenous contrast if there are no contraindications for it; any other clinically-indicated imaging studies if performed (e.g. bone scan) must show no evidence of disease - All patients must have a CT or magnetic resonance imaging (MRI) of the brain within 90 days prior to registration; the brain CT or MRI should be performed with intravenous contrast (unless contraindicated) - Absolute neutrophil count (ANC) >= 1,500 microliter (mcL) (within 42 days prior to registration) - Platelets >= 100,000 mcL (within 42 days prior to registration) - Hemoglobin >= 10 g/dL (within 42 days prior to registration) - Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (except Gilbert's syndrome, who must have a total bilirubin < 3.0 mg/dL) (within 42 days prior to registration) - Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) and serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 2 x IULN (within 42 days prior to registration) - Alkaline phosphatase =< 2 x IULN (within 42 days prior to registration) - Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min (within 42 days prior to registration) - Patients must have lactate dehydrogenase (LDH) performed within 42 days prior to registration - Patients must have Zubrod performance status =< 1 - Patients must have a baseline electrocardiogram (ECG) performed within 42 days of registration that is normal or considered not clinically significant by the site investigator - Patients must not have a history of (non-infectious) pneumonitis that required steroids or current pneumonitis - Patients must not have an active infection requiring systemic therapy - Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment - Patients must not have received live vaccines within 42 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed - Patients known to be human immunodeficiency virus (HIV) positive are eligible if they meet the following criteria within 30 days prior to registration: stable and adequate cluster of differentiation 4 (CD4) counts (>= 350 mm^3), and serum HIV viral load of < 25,000 IU/ml; patients may be on or off anti-viral therapy so long as they meet the CD4 count criteria - Patients must not have known active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection prior to registration - Patients must not have a history or current evidence of any condition, therapy or laboratory abnormality that might confound the trial results, interfere with the patient's participation for the full duration of the trial, or indicate that participation in the trial is not in the patient's best interests, in the opinion of the treating investigator - No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, lobular carcinoma of the breast in situ, atypical melanocytic hyperplasia or melanoma in situ, adequately treated stage I or II cancer (including multiple primary melanomas) from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years - Women of childbearing potential must have a negative urine or serum pregnancy test within 28 days prior to registration; women/men of reproductive potential must have agreed to use an effective contraceptive method for the course of the study through 120 days after the last dose of study medication; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy, or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures, he/she is responsible for beginning contraceptive measures; patients must not be pregnant or nursing due to unknown teratogenic side effects - Patients who are able to complete questionnaires in English, Spanish or French must participate in the quality of life assessments; (those patients who cannot complete the quality of life questionnaires in English, Spanish or French can be registered to S1404 without contributing to the quality of life studies) - Patients must be informed of the investigational nature of this study and must sign and give written informed consent for this protocol in accordance with institutional and federal guidelines - As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system - STEP 2 REGISTRATION (RANDOMIZATION CRITERIA): - Patients must not be registered until receiving confirmation from the Southwest Oncology Group (SWOG) Statistical Center that the patient's tissue specimen was adequate for PD-L1 testing; patients must be registered within 7 working days of receiving the e-mail notification - Women of childbearing potential must plan to have a urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medication; if the urine test is positive or cannot be confirmed as negative, a negative serum pregnancy test will be required - No tests or exams are required to be repeated for step 2 registration (randomization); however, patients who are known to have a change in eligibility status after step 1 registration are not eligible for step 2 registration; for example, ANC is not required to be repeated between step 1 and step 2 registration, but the most recent ANC performed before step 2 registration is required to be >= 1,500 mcL |
Country | Name | City | State |
---|---|---|---|
Canada | Royal Victoria Regional Health Centre | Barrie | Ontario |
Canada | Juravinski Cancer Centre at Hamilton Health Sciences | Hamilton | Ontario |
Canada | Kingston Health Sciences Centre | Kingston | Ontario |
Canada | Grand River Regional Cancer Centre at Grand River Hospital | Kitchener | Ontario |
Canada | Hopital de la Cite-de-la-Sante | Laval | Quebec |
Canada | London Regional Cancer Program | London | Ontario |
Canada | Trillium Health Partners - Credit Valley Hospital | Mississauga | Ontario |
Canada | The Vitalite Health Network - Dr Leon Richard Oncology Centre | Moncton | New Brunswick |
Canada | The Research Institute of the McGill University Health Centre (MUHC) | Montreal | Quebec |
Canada | Lakeridge Health Oshawa | Oshawa | Ontario |
Canada | Ottawa Hospital and Cancer Center-General Campus | Ottawa | Ontario |
Canada | CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) | Quebec City | Quebec |
Canada | Allan Blair Cancer Centre | Regina | Saskatchewan |
Canada | Saskatoon Cancer Centre | Saskatoon | Saskatchewan |
Canada | Algoma District Cancer Program Sault Area Hospital | Sault Ste Marie | Ontario |
Canada | Centre Hospitalier Universitaire de Sherbrooke-Fleurimont | Sherbrooke | Quebec |
Canada | Thunder Bay Regional Health Science Centre | Thunder Bay | Ontario |
Canada | Odette Cancer Centre- Sunnybrook Health Sciences Centre | Toronto | Ontario |
Canada | University Health Network-Princess Margaret Hospital | Toronto | Ontario |
Canada | BCCA-Vancouver Cancer Centre | Vancouver | British Columbia |
Canada | Windsor Regional Cancer Centre | Windsor | Ontario |
Ireland | Saint Vincent's University Hospital | Dublin | Co Dublin |
Ireland | University College Hospital Galway | Galway | Co Galway |
Ireland | University Hospital Waterford | Waterford | Co Waterford |
United States | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington |
United States | Jefferson Abington Hospital | Abington | Pennsylvania |
United States | Lovelace Medical Center-Saint Joseph Square | Albuquerque | New Mexico |
United States | Southwest Gynecologic Oncology Associates Inc | Albuquerque | New Mexico |
United States | University of New Mexico Cancer Center | Albuquerque | New Mexico |
United States | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania |
United States | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah |
United States | Mary Greeley Medical Center | Ames | Iowa |
United States | McFarland Clinic - Ames | Ames | Iowa |
United States | Community Hospital of Anaconda | Anaconda | Montana |
United States | Kaiser Permanente-Anaheim | Anaheim | California |
United States | AnMed Health Cancer Center | Anderson | South Carolina |
United States | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan |
United States | Langlade Hospital and Cancer Center | Antigo | Wisconsin |
United States | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia |
United States | Northside Hospital | Atlanta | Georgia |
United States | Hematology Oncology Associates of Central New York-Auburn | Auburn | New York |
United States | Sutter Auburn Faith Hospital | Auburn | California |
United States | Harold Alfond Center for Cancer Care | Augusta | Maine |
United States | Rush - Copley Medical Center | Aurora | Illinois |
United States | UCHealth University of Colorado Hospital | Aurora | Colorado |
United States | Texas Oncology - Central Austin Cancer Center | Austin | Texas |
United States | Kaiser Permanente-Baldwin Park | Baldwin Park | California |
United States | MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland |
United States | Mercy Medical Center | Baltimore | Maryland |
United States | Eastern Maine Medical Center | Bangor | Maine |
United States | Flaget Memorial Hospital | Bardstown | Kentucky |
United States | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana |
United States | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana |
United States | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana |
United States | Our Lady of the Lake Physician Group | Baton Rouge | Louisiana |
United States | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio |
United States | Kaiser Permanente-Bellflower | Bellflower | California |
United States | Strecker Cancer Center-Belpre | Belpre | Ohio |
United States | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota |
United States | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont |
United States | Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania |
United States | Beverly Hospital | Beverly | Massachusetts |
United States | Billings Clinic Cancer Center | Billings | Montana |
United States | Saint Vincent Healthcare | Billings | Montana |
United States | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama |
United States | Sanford Bismarck Medical Center | Bismarck | North Dakota |
United States | Illinois CancerCare-Bloomington | Bloomington | Illinois |
United States | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho |
United States | Saint Luke's Cancer Institute - Boise | Boise | Idaho |
United States | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri |
United States | McFarland Clinic - Boone | Boone | Iowa |
United States | Beth Israel Deaconess Medical Center | Boston | Massachusetts |
United States | Boston Medical Center | Boston | Massachusetts |
United States | Dana-Farber Cancer Institute | Boston | Massachusetts |
United States | Massachusetts General Hospital Cancer Center | Boston | Massachusetts |
United States | Bozeman Health Deaconess Hospital | Bozeman | Montana |
United States | Lafayette Family Cancer Center-EMMC | Brewer | Maine |
United States | United Hospital Center | Bridgeport | West Virginia |
United States | Roswell Park Cancer Institute | Buffalo | New York |
United States | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin |
United States | Lahey Hospital and Medical Center | Burlington | Massachusetts |
United States | University of Vermont and State Agricultural College | Burlington | Vermont |
United States | University of Vermont Medical Center | Burlington | Vermont |
United States | Fairview Ridges Hospital | Burnsville | Minnesota |
United States | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana |
United States | Illinois CancerCare-Canton | Canton | Illinois |
United States | Saint Francis Medical Center | Cape Girardeau | Missouri |
United States | Southeast Cancer Center | Cape Girardeau | Missouri |
United States | Sandra L Maxwell Cancer Center | Cedar City | Utah |
United States | Physicians' Clinic of Iowa PC | Cedar Rapids | Iowa |
United States | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio |
United States | Miami Valley Hospital South | Centerville | Ohio |
United States | Centralia Oncology Clinic | Centralia | Illinois |
United States | Providence Regional Cancer System-Centralia | Centralia | Washington |
United States | Cancer Center of Kansas - Chanute | Chanute | Kansas |
United States | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina |
United States | Bon Secours Saint Francis Hospital | Charleston | South Carolina |
United States | Charleston Oncology - Roper | Charleston | South Carolina |
United States | Charleston Oncology - Saint Francis | Charleston | South Carolina |
United States | Lowcountry Hematology Oncology PA-North Charleston | Charleston | South Carolina |
United States | Lowcountry Hematology Oncology PA-West Ashley | Charleston | South Carolina |
United States | Roper Hospital | Charleston | South Carolina |
United States | West Virginia University Charleston Division | Charleston | West Virginia |
United States | Northwestern University | Chicago | Illinois |
United States | Rush University Medical Center | Chicago | Illinois |
United States | University of Chicago Comprehensive Cancer Center | Chicago | Illinois |
United States | Adena Regional Medical Center | Chillicothe | Ohio |
United States | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin |
United States | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio |
United States | Case Western Reserve University | Cleveland | Ohio |
United States | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio |
United States | Cleveland Clinic Foundation | Cleveland | Ohio |
United States | MetroHealth Medical Center | Cleveland | Ohio |
United States | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina |
United States | Mercy Cancer Center-West Lakes | Clive | Iowa |
United States | Mission Cancer and Blood - West Des Moines | Clive | Iowa |
United States | Big Horn Basin Cancer Center | Cody | Wyoming |
United States | Billings Clinic-Cody | Cody | Wyoming |
United States | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho |
United States | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado |
United States | UCHealth Memorial Hospital Central | Colorado Springs | Colorado |
United States | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio |
United States | Doctors Hospital | Columbus | Ohio |
United States | Grant Medical Center | Columbus | Ohio |
United States | Mount Carmel East Hospital | Columbus | Ohio |
United States | Mount Carmel Health Center West | Columbus | Ohio |
United States | Ohio State University Comprehensive Cancer Center | Columbus | Ohio |
United States | Riverside Methodist Hospital | Columbus | Ohio |
United States | The Mark H Zangmeister Center | Columbus | Ohio |
United States | Mercy Hospital | Coon Rapids | Minnesota |
United States | UC Irvine Health Cancer Center-Newport | Costa Mesa | California |
United States | Northshore Oncology Associates-Covington | Covington | Louisiana |
United States | Northside Hospital-Forsyth | Cumming | Georgia |
United States | Baylor University Medical Center | Dallas | Texas |
United States | Carle at The Riverfront | Danville | Illinois |
United States | Geisinger Medical Center | Danville | Pennsylvania |
United States | Dayton Physician LLC - Englewood | Dayton | Ohio |
United States | Good Samaritan Hospital - Dayton | Dayton | Ohio |
United States | Miami Valley Hospital | Dayton | Ohio |
United States | Miami Valley Hospital North | Dayton | Ohio |
United States | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois |
United States | Decatur Memorial Hospital | Decatur | Illinois |
United States | Delaware Health Center-Grady Cancer Center | Delaware | Ohio |
United States | Grady Memorial Hospital | Delaware | Ohio |
United States | Kaiser Permanente-Franklin | Denver | Colorado |
United States | Porter Adventist Hospital | Denver | Colorado |
United States | SCL Health Saint Joseph Hospital | Denver | Colorado |
United States | Iowa Methodist Medical Center | Des Moines | Iowa |
United States | Mercy Medical Center - Des Moines | Des Moines | Iowa |
United States | Mission Cancer and Blood - Des Moines | Des Moines | Iowa |
United States | Mission Cancer and Blood - Laurel | Des Moines | Iowa |
United States | Ascension Saint John Hospital | Detroit | Michigan |
United States | Henry Ford Hospital | Detroit | Michigan |
United States | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan |
United States | Cancer Center of Kansas - Dodge City | Dodge City | Kansas |
United States | Wentworth-Douglass Hospital | Dover | New Hampshire |
United States | City of Hope Comprehensive Cancer Center | Duarte | California |
United States | Essentia Health Cancer Center | Duluth | Minnesota |
United States | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota |
United States | Miller-Dwan Hospital | Duluth | Minnesota |
United States | Duke University Medical Center | Durham | North Carolina |
United States | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan |
United States | Veterans Adminstration New Jersey Health Care System | East Orange | New Jersey |
United States | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York |
United States | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin |
United States | Fairview Southdale Hospital | Edina | Minnesota |
United States | Carle Physician Group-Effingham | Effingham | Illinois |
United States | Crossroads Cancer Center | Effingham | Illinois |
United States | Cancer Center of Kansas - El Dorado | El Dorado | Kansas |
United States | Elmhurst Memorial Hospital | Elmhurst | Illinois |
United States | Ephrata Cancer Center | Ephrata | Pennsylvania |
United States | Ephrata Community Hospital | Ephrata | Pennsylvania |
United States | UPMC Hillman Cancer Center Erie | Erie | Pennsylvania |
United States | OSF Saint Francis Hospital and Medical Group | Escanaba | Michigan |
United States | Illinois CancerCare-Eureka | Eureka | Illinois |
United States | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois |
United States | Providence Regional Cancer Partnership | Everett | Washington |
United States | Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut |
United States | Sanford Broadway Medical Center | Fargo | North Dakota |
United States | Sanford Clinic North-Fargo | Fargo | North Dakota |
United States | Sanford Roger Maris Cancer Center | Fargo | North Dakota |
United States | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota |
United States | Armes Family Cancer Center | Findlay | Ohio |
United States | Blanchard Valley Hospital | Findlay | Ohio |
United States | Orion Cancer Care | Findlay | Ohio |
United States | Genesys Hurley Cancer Institute | Flint | Michigan |
United States | Hurley Medical Center | Flint | Michigan |
United States | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin |
United States | Saint Agnes Hospital/Agnesian Cancer Center | Fond Du Lac | Wisconsin |
United States | Kaiser Permanente-Fontana | Fontana | California |
United States | Poudre Valley Hospital | Fort Collins | Colorado |
United States | McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa |
United States | Frederick Memorial Hospital | Frederick | Maryland |
United States | Kaiser Permanente-Fremont | Fremont | California |
United States | Palo Alto Medical Foundation-Fremont | Fremont | California |
United States | Kaiser Permanente-Fresno | Fresno | California |
United States | Unity Hospital | Fridley | Minnesota |
United States | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho |
United States | Illinois CancerCare-Galesburg | Galesburg | Illinois |
United States | Saint Catherine Hospital | Garden City | Kansas |
United States | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois |
United States | Aurora Health Care Germantown Health Center | Germantown | Wisconsin |
United States | The West Clinic - Wolf River | Germantown | Tennessee |
United States | Adams Cancer Center | Gettysburg | Pennsylvania |
United States | Glens Falls Hospital | Glens Falls | New York |
United States | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois |
United States | Addison Gilbert Hospital | Gloucester | Massachusetts |
United States | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina |
United States | Wayne Memorial Hospital | Goldsboro | North Carolina |
United States | Aurora Cancer Care-Grafton | Grafton | Wisconsin |
United States | Altru Cancer Center | Grand Forks | North Dakota |
United States | Nebraska Cancer Specialists/Oncology Hematology West PC | Grand Island | Nebraska |
United States | Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan |
United States | Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan |
United States | Central Care Cancer Center - Great Bend | Great Bend | Kansas |
United States | Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas |
United States | Benefis Sletten Cancer Institute | Great Falls | Montana |
United States | Great Falls Clinic | Great Falls | Montana |
United States | Banner North Colorado Medical Center | Greeley | Colorado |
United States | Aurora BayCare Medical Center | Green Bay | Wisconsin |
United States | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin |
United States | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin |
United States | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin |
United States | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin |
United States | Saint Francis Cancer Center | Greenville | South Carolina |
United States | Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan |
United States | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan |
United States | Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan |
United States | Hackensack University Medical Center | Hackensack | New Jersey |
United States | WellSpan Medical Oncology and Hematology | Hanover | Pennsylvania |
United States | Kaiser Permanente - Harbor City | Harbor City | California |
United States | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut |
United States | HaysMed | Hays | Kansas |
United States | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania |
United States | Saint Peter's Community Hospital | Helena | Montana |
United States | Cancer and Blood Specialists-Henderson | Henderson | Nevada |
United States | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada |
United States | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada |
United States | GenesisCare USA - Henderson | Henderson | Nevada |
United States | Las Vegas Cancer Center-Henderson | Henderson | Nevada |
United States | Hendersonville Hematology and Oncology at Pardee | Hendersonville | North Carolina |
United States | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina |
United States | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania |
United States | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois |
United States | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii |
United States | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii |
United States | Island Urology | Honolulu | Hawaii |
United States | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii |
United States | Queen's Cancer Center - Kuakini | Honolulu | Hawaii |
United States | Queen's Medical Center | Honolulu | Hawaii |
United States | Straub Clinic and Hospital | Honolulu | Hawaii |
United States | Tripler Army Medical Center | Honolulu | Hawaii |
United States | University of Hawaii Cancer Center | Honolulu | Hawaii |
United States | M D Anderson Cancer Center | Houston | Texas |
United States | Centerpoint Medical Center LLC | Independence | Missouri |
United States | Cleveland Clinic Cancer Center Independence | Independence | Ohio |
United States | Community Cancer Center East | Indianapolis | Indiana |
United States | Community Cancer Center North | Indianapolis | Indiana |
United States | Community Cancer Center South | Indianapolis | Indiana |
United States | Franciscan Health Indianapolis | Indianapolis | Indiana |
United States | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana |
United States | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa |
United States | Green Bay Oncology - Iron Mountain | Iron Mountain | Michigan |
United States | Kaiser Permanente-Irvine | Irvine | California |
United States | Allegiance Health | Jackson | Michigan |
United States | University of Mississippi Medical Center | Jackson | Mississippi |
United States | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina |
United States | McFarland Clinic - Jefferson | Jefferson | Iowa |
United States | MU Health Care Goldschmidt Cancer Center | Jefferson City | Missouri |
United States | West Michigan Cancer Center | Kalamazoo | Michigan |
United States | Kalispell Regional Medical Center | Kalispell | Montana |
United States | Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri |
United States | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri |
United States | Research Medical Center | Kansas City | Missouri |
United States | Saint Luke's Hospital of Kansas City | Kansas City | Missouri |
United States | The University of Kansas Cancer Center-South | Kansas City | Missouri |
United States | University Health Truman Medical Center | Kansas City | Missouri |
United States | University of Kansas Cancer Center | Kansas City | Kansas |
United States | University of Kansas Cancer Center - North | Kansas City | Missouri |
United States | University of Kansas Cancer Center-West | Kansas City | Kansas |
United States | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin |
United States | Greater Dayton Cancer Center | Kettering | Ohio |
United States | Kettering Medical Center | Kettering | Ohio |
United States | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois |
United States | Gundersen Lutheran Medical Center | La Crosse | Wisconsin |
United States | UC San Diego Moores Cancer Center | La Jolla | California |
United States | Providence Regional Cancer System-Lacey | Lacey | Washington |
United States | Kaiser Permanente-Rock Creek | Lafayette | Colorado |
United States | Lakeland Regional Health Hollis Cancer Center | Lakeland | Florida |
United States | University of Michigan Health - Sparrow Lansing | Lansing | Michigan |
United States | Ann M Wierman MD LTD | Las Vegas | Nevada |
United States | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada |
United States | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada |
United States | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada |
United States | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada |
United States | GenesisCare USA - Las Vegas | Las Vegas | Nevada |
United States | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada |
United States | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada |
United States | University Cancer Center | Las Vegas | Nevada |
United States | University Medical Center of Southern Nevada | Las Vegas | Nevada |
United States | Lawrence Memorial Hospital | Lawrence | Kansas |
United States | Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | New Hampshire |
United States | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri |
United States | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri |
United States | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas |
United States | Minimally Invasive Surgery Hospital | Lenexa | Kansas |
United States | Saint Joseph Hospital East | Lexington | Kentucky |
United States | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky |
United States | Cancer Center of Kansas-Liberal | Liberal | Kansas |
United States | Liberty Radiation Oncology Center | Liberty | Missouri |
United States | Cancer Partners of Nebraska | Lincoln | Nebraska |
United States | Nebraska Hematology and Oncology | Lincoln | Nebraska |
United States | University of Arkansas for Medical Sciences | Little Rock | Arkansas |
United States | Littleton Adventist Hospital | Littleton | Colorado |
United States | Saint Barnabas Medical Center | Livingston | New Jersey |
United States | Logan Regional Hospital | Logan | Utah |
United States | Kaiser Permanente-Lone Tree | Lone Tree | Colorado |
United States | PeaceHealth Saint John Medical Center | Longview | Washington |
United States | Cedars Sinai Medical Center | Los Angeles | California |
United States | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California |
United States | Kaiser Permanente West Los Angeles | Los Angeles | California |
United States | Los Angeles General Medical Center | Los Angeles | California |
United States | UCLA / Jonsson Comprehensive Cancer Center | Los Angeles | California |
United States | USC / Norris Comprehensive Cancer Center | Los Angeles | California |
United States | Saints Mary and Elizabeth Hospital | Louisville | Kentucky |
United States | UofL Health Medical Center Northeast | Louisville | Kentucky |
United States | Centra Alan B Pearson Regional Cancer Center | Lynchburg | Virginia |
United States | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan |
United States | Illinois CancerCare-Macomb | Macomb | Illinois |
United States | Michigan Breast Specialists-Macomb Township | Macomb | Michigan |
United States | University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin |
United States | Dartmouth Cancer Center - Manchester | Manchester | New Hampshire |
United States | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio |
United States | OhioHealth Mansfield Hospital | Mansfield | Ohio |
United States | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota |
United States | Saint John's Hospital - Healtheast | Maplewood | Minnesota |
United States | Marietta Memorial Hospital | Marietta | Ohio |
United States | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin |
United States | Bay Area Medical Center | Marinette | Wisconsin |
United States | OhioHealth Marion General Hospital | Marion | Ohio |
United States | McFarland Clinic - Marshalltown | Marshalltown | Iowa |
United States | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin |
United States | Fremont - Rideout Cancer Center | Marysville | California |
United States | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois |
United States | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio |
United States | Loyola University Medical Center | Maywood | Illinois |
United States | Cancer Center of Kansas - McPherson | McPherson | Kansas |
United States | The West Clinic - Mid-Town | Memphis | Tennessee |
United States | University of Tennessee Health Science Center | Memphis | Tennessee |
United States | Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin |
United States | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho |
United States | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida |
United States | Mount Sinai Medical Center | Miami Beach | Florida |
United States | Ascension Southeast Wisconsin Hospital - Saint Joseph Campus | Milwaukee | Wisconsin |
United States | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin |
United States | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin |
United States | Aurora Sinai Medical Center | Milwaukee | Wisconsin |
United States | Medical College of Wisconsin | Milwaukee | Wisconsin |
United States | Abbott-Northwestern Hospital | Minneapolis | Minnesota |
United States | Hennepin County Medical Center | Minneapolis | Minnesota |
United States | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin |
United States | Community Medical Center | Missoula | Montana |
United States | Saint Patrick Hospital - Community Hospital | Missoula | Montana |
United States | Kaiser Permanente-Modesto | Modesto | California |
United States | Memorial Medical Center | Modesto | California |
United States | Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana |
United States | Franciscan Health Mooresville | Mooresville | Indiana |
United States | West Virginia University Healthcare | Morgantown | West Virginia |
United States | Lowcountry Hematology Oncology PA-Mount Pleasant | Mount Pleasant | South Carolina |
United States | Knox Community Hospital | Mount Vernon | Ohio |
United States | Palo Alto Medical Foundation-Camino Division | Mountain View | California |
United States | Intermountain Medical Center | Murray | Utah |
United States | Trinity Health Muskegon Hospital | Muskegon | Michigan |
United States | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho |
United States | Edward Hospital/Cancer Center | Naperville | Illinois |
United States | Dartmouth Cancer Center - Nashua | Nashua | New Hampshire |
United States | Saint Joseph Hospital | Nashua | New Hampshire |
United States | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee |
United States | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey |
United States | Yale University | New Haven | Connecticut |
United States | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois |
United States | Cancer Center of Western Wisconsin | New Richmond | Wisconsin |
United States | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York |
United States | Christiana Care Health System-Christiana Hospital | Newark | Delaware |
United States | Helen F Graham Cancer Center | Newark | Delaware |
United States | Licking Memorial Hospital | Newark | Ohio |
United States | Medical Oncology Hematology Consultants PA | Newark | Delaware |
United States | Newport Hospital | Newport | Rhode Island |
United States | USC Norris Oncology/Hematology-Newport Beach | Newport Beach | California |
United States | Cancer Center of Kansas - Newton | Newton | Kansas |
United States | Faith Regional Health Services Carson Cancer Center | Norfolk | Nebraska |
United States | Sutter Cancer Research Consortium | Novato | California |
United States | Cancer Care Center of O'Fallon | O'Fallon | Illinois |
United States | Kaiser Permanente-Oakland | Oakland | California |
United States | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin |
United States | McKay-Dee Hospital Center | Ogden | Utah |
United States | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma |
United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
United States | Olathe Health Cancer Center | Olathe | Kansas |
United States | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska |
United States | Alegent Health Immanuel Medical Center | Omaha | Nebraska |
United States | Alegent Health Lakeside Hospital | Omaha | Nebraska |
United States | Creighton University Medical Center | Omaha | Nebraska |
United States | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska |
United States | Nebraska Methodist Hospital | Omaha | Nebraska |
United States | Saint Joseph Hospital - Orange | Orange | California |
United States | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California |
United States | University of Chicago Medicine-Orland Park | Orland Park | Illinois |
United States | Orlando Health Cancer Institute | Orlando | Florida |
United States | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin |
United States | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois |
United States | Menorah Medical Center | Overland Park | Kansas |
United States | Saint Luke's South Hospital | Overland Park | Kansas |
United States | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas |
United States | Owensboro Health Mitchell Memorial Cancer Center | Owensboro | Kentucky |
United States | Palo Alto Medical Foundation Health Care | Palo Alto | California |
United States | Stanford Cancer Institute Palo Alto | Palo Alto | California |
United States | Kaiser Permanente - Panorama City | Panorama City | California |
United States | Parker Adventist Hospital | Parker | Colorado |
United States | Camden Clark Medical Center | Parkersburg | West Virginia |
United States | University Hospitals Parma Medical Center | Parma | Ohio |
United States | Cancer Center of Kansas - Parsons | Parsons | Kansas |
United States | Illinois CancerCare-Pekin | Pekin | Illinois |
United States | Illinois CancerCare-Peoria | Peoria | Illinois |
United States | Illinois CancerCare-Peru | Peru | Illinois |
United States | Fox Chase Cancer Center | Philadelphia | Pennsylvania |
United States | Cancer Center at Saint Joseph's | Phoenix | Arizona |
United States | Ascension Via Christi - Pittsburg | Pittsburg | Kansas |
United States | Allegheny General Hospital | Pittsburgh | Pennsylvania |
United States | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania |
United States | West Penn Hospital | Pittsburgh | Pennsylvania |
United States | Edward Hospital/Cancer Center?Plainfield | Plainfield | Illinois |
United States | Kaiser Permanente Northwest | Portland | Oregon |
United States | Oregon Health and Science University | Portland | Oregon |
United States | Providence Portland Medical Center | Portland | Oregon |
United States | Southern Ohio Medical Center | Portsmouth | Ohio |
United States | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho |
United States | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania |
United States | Illinois CancerCare-Princeton | Princeton | Illinois |
United States | Miriam Hospital | Providence | Rhode Island |
United States | Rhode Island Hospital | Providence | Rhode Island |
United States | Utah Valley Regional Medical Center | Provo | Utah |
United States | Aurora Cancer Care-Racine | Racine | Wisconsin |
United States | Rapid City Regional Hospital | Rapid City | South Dakota |
United States | Kaiser Permanente-Redwood City | Redwood City | California |
United States | Corewell Health Reed City Hospital | Reed City | Michigan |
United States | Beebe Health Campus | Rehoboth Beach | Delaware |
United States | Lakeview Medical Center-Marshfield Clinic | Rice Lake | Wisconsin |
United States | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin |
United States | Kaiser Permanente-Richmond | Richmond | California |
United States | Reid Health | Richmond | Indiana |
United States | Virginia Cancer Institute | Richmond | Virginia |
United States | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia |
United States | Kaiser Permanente-Riverside | Riverside | California |
United States | Rochester General Hospital | Rochester | New York |
United States | University of Rochester | Rochester | New York |
United States | Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills | Michigan |
United States | UW Health Carbone Cancer Center Rockford | Rockford | Illinois |
United States | Highlands Oncology Group - Rogers | Rogers | Arkansas |
United States | Kaiser Permanente-Roseville | Roseville | California |
United States | Sutter Roseville Medical Center | Roseville | California |
United States | Kaiser Permanente - Sacramento | Sacramento | California |
United States | Kaiser Permanente-South Sacramento | Sacramento | California |
United States | Sutter Medical Center Sacramento | Sacramento | California |
United States | University of California Davis Comprehensive Cancer Center | Sacramento | California |
United States | Ascension Saint Mary's Hospital | Saginaw | Michigan |
United States | Saint George Regional Medical Center | Saint George | Utah |
United States | Heartland Regional Medical Center | Saint Joseph | Missouri |
United States | Missouri Baptist Medical Center | Saint Louis | Missouri |
United States | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota |
United States | Regions Hospital | Saint Paul | Minnesota |
United States | United Hospital | Saint Paul | Minnesota |
United States | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri |
United States | Cancer Center of Kansas - Salina | Salina | Kansas |
United States | Salina Regional Health Center | Salina | Kansas |
United States | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah |
United States | LDS Hospital | Salt Lake City | Utah |
United States | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah |
United States | Kaiser Permanente-San Diego Mission | San Diego | California |
United States | Kaiser Permanente-San Diego Zion | San Diego | California |
United States | California Pacific Medical Center-Pacific Campus | San Francisco | California |
United States | Kaiser Permanente-San Francisco | San Francisco | California |
United States | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California |
United States | Kaiser Permanente San Leandro | San Leandro | California |
United States | Kaiser Permanente-San Marcos | San Marcos | California |
United States | Kaiser Permanente-San Rafael | San Rafael | California |
United States | Kootenai Cancer Clinic | Sandpoint | Idaho |
United States | North Coast Cancer Care | Sandusky | Ohio |
United States | UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio |
United States | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California |
United States | Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California |
United States | Kaiser Permanente-Santa Rosa | Santa Rosa | California |
United States | Sutter Pacific Medical Foundation | Santa Rosa | California |
United States | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia |
United States | Memorial Health University Medical Center | Savannah | Georgia |
United States | Maine Center for Cancer Medicine-Scarborough | Scarborough | Maine |
United States | Regional West Medical Center Cancer Center | Scottsbluff | Nebraska |
United States | Virginia G Piper Cancer Care-Del Camino | Scottsdale | Arizona |
United States | Kaiser Permanente Washington | Seattle | Washington |
United States | Swedish Medical Center-First Hill | Seattle | Washington |
United States | HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin |
United States | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin |
United States | Providence Regional Cancer System-Shelton | Shelton | Washington |
United States | Welch Cancer Center | Sheridan | Wyoming |
United States | LSU Health Sciences Center at Shreveport | Shreveport | Louisiana |
United States | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota |
United States | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota |
United States | VCU Community Memorial Health Center | South Hill | Virginia |
United States | South Jordan Health Center | South Jordan | Utah |
United States | Kaiser Permanente-South San Francisco | South San Francisco | California |
United States | Baystate Medical Center | Springfield | Massachusetts |
United States | Central Illinois Hematology Oncology Center | Springfield | Illinois |
United States | CoxHealth South Hospital | Springfield | Missouri |
United States | Memorial Medical Center | Springfield | Illinois |
United States | Mercy Hospital Springfield | Springfield | Missouri |
United States | Southern Illinois University School of Medicine | Springfield | Illinois |
United States | Springfield Clinic | Springfield | Illinois |
United States | Stamford Hospital/Bennett Cancer Center | Stamford | Connecticut |
United States | Ascension Saint Michael's Hospital | Stevens Point | Wisconsin |
United States | Kaiser Permanente-Stockton | Stockton | California |
United States | Stony Brook University Medical Center | Stony Brook | New York |
United States | Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio |
United States | Green Bay Oncology - Sturgeon Bay | Sturgeon Bay | Wisconsin |
United States | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin |
United States | Missouri Baptist Sullivan Hospital | Sullivan | Missouri |
United States | Aurora Medical Center in Summit | Summit | Wisconsin |
United States | Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California |
United States | ProMedica Flower Hospital | Sylvania | Ohio |
United States | Hematology Oncology Associates of Central New York-Onondaga Hill | Syracuse | New York |
United States | State University of New York Upstate Medical University | Syracuse | New York |
United States | Moffitt Cancer Center | Tampa | Florida |
United States | University of Toledo | Toledo | Ohio |
United States | University of Kansas Health System Saint Francis Campus | Topeka | Kansas |
United States | Munson Medical Center | Traverse City | Michigan |
United States | Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California |
United States | Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut |
United States | Banner University Medical Center - Tucson | Tucson | Arizona |
United States | University of Arizona Cancer Center-North Campus | Tucson | Arizona |
United States | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho |
United States | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin |
United States | Carle Cancer Center | Urbana | Illinois |
United States | The Carle Foundation Hospital | Urbana | Illinois |
United States | Kaiser Permanente Medical Center-Vacaville | Vacaville | California |
United States | South Georgia Medical Center/Pearlman Cancer Center | Valdosta | Georgia |
United States | Kaiser Permanente-Vallejo | Vallejo | California |
United States | PeaceHealth Southwest Medical Center | Vancouver | Washington |
United States | Ridgeview Medical Center | Waconia | Minnesota |
United States | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington |
United States | Kaiser Permanente-Walnut Creek | Walnut Creek | California |
United States | Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan |
United States | Saint John Macomb-Oakland Hospital | Warren | Michigan |
United States | South Pointe Hospital | Warrensville Heights | Ohio |
United States | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois |
United States | MedStar Georgetown University Hospital | Washington | District of Columbia |
United States | MedStar Washington Hospital Center | Washington | District of Columbia |
United States | Aspirus Regional Cancer Center | Wausau | Wisconsin |
United States | Marshfield Clinic-Wausau Center | Wausau | Wisconsin |
United States | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin |
United States | Cancer Center of Kansas - Wellington | Wellington | Kansas |
United States | Aurora West Allis Medical Center | West Allis | Wisconsin |
United States | Mercy Medical Center-West Lakes | West Des Moines | Iowa |
United States | Reading Hospital | West Reading | Pennsylvania |
United States | Saint Ann's Hospital | Westerville | Ohio |
United States | Cleveland Clinic-Weston | Weston | Florida |
United States | Marshfield Medical Center - Weston | Weston | Wisconsin |
United States | Wexford Health and Wellness Pavilion | Wexford | Pennsylvania |
United States | Ascension Via Christi Hospitals Wichita | Wichita | Kansas |
United States | Cancer Center of Kansas - Wichita | Wichita | Kansas |
United States | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas |
United States | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania |
United States | UPMC Susquehanna | Williamsport | Pennsylvania |
United States | Cancer Center of Kansas - Winfield | Winfield | Kansas |
United States | Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin |
United States | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin |
United States | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota |
United States | Kaiser Permanente-Woodland Hills | Woodland Hills | California |
United States | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio |
United States | University of Michigan Health - West | Wyoming | Michigan |
United States | Providence Regional Cancer System-Yelm | Yelm | Washington |
United States | WellSpan Health-York Cancer Center | York | Pennsylvania |
United States | WellSpan Health-York Hospital | York | Pennsylvania |
United States | Rush-Copley Healthcare Center | Yorkville | Illinois |
United States | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio |
Lead Sponsor | Collaborator |
---|---|
National Cancer Institute (NCI) |
United States, Canada, Ireland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Overall survival (OS) | From date of randomization to date of death due to any cause. Patients last known to be alive were censored at date of last contact. OS estimates will be calculated using the method of Kaplan-Meier. Comparison between arms will be performed using a stratified log-rank test in the intent-to-treat population. | Up to 10 years from date of randomization | |
Primary | Relapse-free survival (RFS) | From date of randomization to date of first documentation of disease recurrence (relapse) or death due to any cause. On study disease assessments by imaging were to be performed every 12 weeks until 2 years from randomization, and then every 6 months until 5 years from randomization. Patients last known to be alive and relapse-free were censored at date of last contact. RFS estimates will be calculated using the method of Kaplan-Meier. Comparison between arms will be performed using a stratified log-rank test in the intent-to-treat population. | Up to 5 years from date of randomization | |
Primary | Overall Survival among patients with PD-L1 positive tumors | From date of randomization to date of death due to any cause. Patients last known to be alive were censored at date of last contact. OS estimates will be calculated using the method of Kaplan-Meier. Comparison between arms will be performed using a stratified log-rank test in the intent-to-treat population among those patients with PD-L1 positive tumors.
PD-L1 expression was evaluated by immunohistochemistry (IHC) assay on archival or fresh tumor tissue using the 22C3 antibody and was scored on a scale of 0 to 5 (with higher numbers reflecting a higher level of PD-L1 expression); a score of 2 or higher (staining on greater than 1% of cells) was considered to indicate PD-L1 positivity. |
Up to 10 years from randomization | |
Secondary | Relapse-free survival among patients with PD-L1 positive tumors | From date of randomization to date of first documentation of disease recurrence (relapse) or death due to any cause. On study disease assessments by imaging were to be performed every 12 weeks until 2 years from randomization, and then every 6 months until 5 years from randomization. Patients last known to be alive and relapse-free were censored at date of last contact. RFS estimates will be calculated using the method of Kaplan-Meier. Comparison between arms will be performed using a stratified log-rank test in the intent-to-treat population among those patients with PD-L1 positive tumors.
PD-L1 expression was evaluated by immunohistochemistry (IHC) assay on archival or fresh tumor tissue using the 22C3 antibody and was scored on a scale of 0 to 5 (with higher numbers reflecting a higher level of PD-L1 expression); a score of 2 or higher (staining on greater than 1% of cells) was considered to indicate PD-L1 positivity. |
Up to 5 years from the date of randomization | |
Secondary | Overall Survival among patients with PD-L1 negative tumors | From date of randomization to date of death due to any cause. Patients last known to be alive will be censored at date of last contact. OS estimates will be calculated using the method of Kaplan-Meier. Cox regression models will be used to estimate hazard ratios and calculate confidence intervals to compare treatment arms in the PD-L1 negative subgroup. In addition Cox regression models for OS will be used to estimate interaction terms between PD-L1 status and treatment arm.
PD-L1 expression was evaluated by immunohistochemistry (IHC) assay on archival or fresh tumor tissue using the 22C3 antibody and was scored on a scale of 0 to 5 (with higher numbers reflecting a higher level of PD-L1 expression); a score of 0-1 (staining on = 1% of cells) was considered to indicate PD-L1 negative status. |
Up to 10 years from date of randomization | |
Secondary | RFS among patients with PD-L1 negative tumors | From date of randomization to date of first documentation of disease recurrence (relapse) or death due to any cause. On study disease assessments by imaging were to be performed every 12 weeks until 2 years from randomization, and then every 6 months until 5 years from randomization. Patients last known to be alive and relapse-free were censored at date of last contact. RFS estimates will be calculated using the method of Kaplan-Meier. Cox regression models will be used to estimate hazard ratios and calculate confidence intervals to compare treatment arms in the PD-L1 negative subgroup. In addition Cox regression models for RFS will be used to estimate interaction terms between PD-L1 status and treatment arm.
PD-L1 expression was evaluated by IHC assay on archival or fresh tumor tissue using the 22C3 antibody and was scored on a scale of 0 to 5; a score of 2 or higher was considered to indicate PD-L1 positivity. a score of 0-1 was considered to indicate PD-L1 negative status. |
Up to 5 years from the date of randomization. | |
Secondary | Incidence of toxicity | The proportion of patients experiencing a particular adverse event (AE), as defined by the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 (CTCAE version 5.0 beginning April 1, 2018), for each treatment regimen using the number of patients who received at least one dose of that regimen as the denominator. AEs are AE proportions will be estimated along with a 95% confidence intervals. | Up to 30 days after the last study drug administration |
Status | Clinical Trial | Phase | |
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