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Celecoxib for the Treatment of Non-muscle Invasive Bladder Cancer

Non Muscle Invasive Bladder Cancer Clinical Trial

Official title:
Celecoxib for the Treatment of Non-muscle Invasive Bladder Cancer

Clinical Trial Summary

The treatment of non-muscle invasive bladder cancer (NMIBC) is problematic given the variable natural history of the disease. Although contemporary treatment options are limited, new targets and new approaches are under investigation for preventing bladder cancer recurrence and progression. Among those, COX-2 is a promising target since plays an important role in urothelial carcinogenesis and iCOX-2 selective inhibitors, like celecoxib, effectively inhibit tumor development and growth and enhances survival, in bladder cancer in vitro and in vivo models.

Therefore, the investigators conducted a pilot study of celecoxib to prevent recurrence in patients with intermediate risk NMIBC.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02343614
Study type Interventional
Source Azienda Ospedaliero-Universitaria Consorziale
Contact
Status Completed
Phase Phase 2
Start date March 2003
Completion date January 2014
View Details
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