CT Perfusion and MRI Perfusion in Solid Tumors Clinical Trial
— PerfusionOfficial title:
Diagnostic and Clinical Accuracy of Integrated Magnetic Resonance Imaging and Computed Tomography Perfusion in PET/MRI in Comparison to PET/CT in Solid Tumors
| Verified date | December 2016 |
| Source | University of Zurich |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | Switzerland: Ethikkommission |
| Study type | Observational |
Diagnostic comparison between PET/CT and PET/MRI with integrated perfusion measurement in CT and MR. Study aim is to gain knowledge about additional value of CT perfusion and MR perfusion in solid tumors concerning tumor physiology, diagnostic accuracy and possibly prognostic.
| Status | Terminated |
| Enrollment | 43 |
| Est. completion date | December 2016 |
| Est. primary completion date | December 2016 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 30 Years to 90 Years |
| Eligibility |
Inclusion Criteria: - indication as stated above - written informed consent - patients with suspected or confirmed solid malignant tumors of the neck, chest or abdomen who have an indication for a PET/CT Exclusion Criteria: - pregnant or breast feeding women - non compliance of the patient to follow the study instructions (e.g. hearing problems, dementia) - Inclusion in another clinical trial 30 days prior to inclusion - age < 30years - contraindication for MRI (cardiac pacemaker, certain metal implants, claustrophobia - known allergies to contrast CT or MRI contrast media - patients with an glomerular filtration rate of < 60ml/min/1.73m2 |
Observational Model: Case-Only, Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| Switzerland | University Hospital Zurich, Diagnostic and Interventional Radiology | Zurich | ZH |
| Lead Sponsor | Collaborator |
|---|---|
| University of Zurich |
Switzerland,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Other | Measurement of blood flow (mL/100 mg tissue/min) with CT-Perfusion and PET/MR-perfusion in solid tumors. | 18 months | No | |
| Other | Measurement of blood volume (mL/100 mg tissue) with CT-Perfusion and PET/MR-perfusion in solid tumors. | 18 months | No | |
| Other | Measurement of transfer constant with PET/MR-perfusion in solid tumors. | 18 months | No | |
| Primary | Measurement of blood flow, blood volume and transfer constant (Ktrans) with CT-Perfusion and PET/MR-perfusion in solid tumors. | 18 months | No | |
| Secondary | Correlation of blood flow, blood volume and transfer constant (Ktrans) measured with CT-Perfusion and PET/MR-perfusion with progression free survival in solid tumors. | 18 months | No |