Need for Renal Replacement Therapy and Anti-infective Therapy Due to Severe Infection Clinical Trial
Official title:
Drugmonitoring of Antiinfective Drugs in Patients Receiving Continous Veno-venous Hemodiafiltration
Approximately 300 patients have to be enrolled in the study. They are followed up until the
end of ICU stay. Usually in clinical routine, patients suspected to have infection and
simultaneously renal dysfunction making CVVHDF necessary. After enrolment blood and
dialysate specimens are drawn and sent for analysis on specific time points. The analysis
results are sent back to the study team at the Charité - Universitätsmedizin Berlin and
enable them to optimize antiinfectiva treatment of the study patients.
Data are used to test calculation tools and modify them if necessary.
Little data exist whether desired and necessary blood levels of antiinfective drugs are
reached during renal replacement therapy. Drug producing companies are not able to come
forward with appropriate dosing recommendation in patients needing renal replacement
therapy.
To achieve our study goal we plan:
1. To measure serum-concentrations of antiinfective drugs applied to the patients
2. To measure concentrations of antiinfective drugs in hemofiltration fluids.
3. To compare the actual measured concentrations with concentration predicted in known
calculation tools.
4. To modify these calculation tools if necessary for better prediction.
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Observational Model: Cohort, Time Perspective: Prospective