| Eligibility |
Inclusion Criteria:
- Histologically confirmed diagnosis of GIST that is metastatic. Patients with the
primary tumor still in place are excluded from the trial, due to the risk for
intestinal perforation reported for cabozantinib.
- Presence of at least one non-previously irradiated, measurable metastatic lesion as
defined by RECIST 1.1.
- Archival tumor tissue available from primary tumor or metastatic site (10 unstained
slides with archived tumor tissue of 10 micrometer thickness and two hematoxylin and
eosin (H&E) stained slides) for central mutational analysis; Note: slides are
preferred material but if not available blocks are accepted
- Failure on prior therapy with
- Interval from prior TKI therapy to the first dose of cabozantinib should be at
least 14 days
- Radiological progression on imatinib during neoadjuvant, adjuvant or palliative
treatment of GIST or within 3 months after completing adjuvant treatment with
imatinib AND radiological progression on sunitinib for the treatment of advanced
GIST
Note: progression is assessed by local radiologist/oncologist without central confirmation
of pre-baseline progression.
- Agreement of the patient to allow sequential sampling of circulating cell-free DNA for
central mutational analysis is mandatory.
- Male or female patient = 18 years of age
- ECOG (Eastern Cooperative Oncology Group) performance status (PS) of 0-1
- Adequate bone marrow and organ function as defined by the following laboratory values
assessed within = 14 days prior to receiving the first dose of study treatment:
- ANC (Absolute Count Neutrophils) = 1.5 x 10exp9/L (no prophylactic administration
of G-CSF (Granulocyte Colony Stimulating Factor) or GM (Granulocyte Macrophage)
-CSF allowed).
- Platelet count = 100 x 10exp9/L or x 10exp3/µL (transfusion allowed).
- Hemoglobin = 9.0 g/dL or 5.6 mmol/L (transfusion and erythropoietin allowed).
- Prothrombin time (PT)/ INR (International Normalized Ratio) or partial
thromboplastin time (PTT) test < 1.3 X ULN within 7 days before the first dose of
study treatment; Note: patients requiring concomitant treatment, in therapeutic
doses, with anticoagulants such as warfarin or warfarin-related agents, heparin,
thrombin or Factor Xa inhibitors, or antiplatelet agents (eg, clopidogrel) are
not eligible. Low dose aspirin (= 81 mg/day), low-dose warfarin (= 1 mg/day), and
prophylactic LMWH (Low Molecular Weight Heparin) are permitted;
- Potassium, calcium, magnesium and phosphorous within normal limits of the
institution or corrected to within normal limits prior to the first dose of study
medication.
- Serum creatinine = 1.5 x upper limit of normal (ULN) or calculated creatinine
clearance = 50 mL/min or GFR >30 mL/min (as assessed per local standard).
- Serum bilirubin within normal range (or = 1.5 x ULN if liver metastases are
present; or total bilirubin = 3.0 x ULN with direct bilirubin within normal range
in patients with Gilbert's syndrome).
- Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within
= 3.0 x ULN.
- Serum albumin = 2.8 g/dL.
- Serum lipase < 2 x ULN and no radiologic or clinical evidence of pancreatitis
- Urine protein/creatinine ratio (UPCR) = 1.
- Clinically normal cardiac function based on the institutional lower limit of normal
for left ventricular ejection fraction as assessed either by multi-gated acquisition
scan or cardiac ultrasound, 12 lead ECG without clinically relevant abnormalities
(stable atrial fibrillation allowed), no history of congenital long QT syndrome, no
prolongation of corrected QT interval (QTcF) > 500 msec according to Fridericia's
formula), and no history of any one of the following cardiovascular conditions within
the past 6 months:
- Cardiac angioplasty or stenting.
- Myocardial infarction.
- Unstable angina.
- Coronary artery bypass graft surgery.
- Clinically significant cardiac arrhythmias
- Symptomatic peripheral vascular disease.
- Class III or IV congestive heart failure, as defined by the New York Heart
Association (NYHA).
- Patients must be able to swallow and retain oral film-coated tablets.
- Recovery to baseline or = Grade 1 CTCAE v.4.0 from toxicities related to any prior
treatments, unless AE(s) are clinically non significant and/or stable on supportive
therapy;
- Prior surgery:
- Minor surgery (including uncomplicated tooth extractions) within 28 days before
the first dose of study treatment with complete wound healing at least 10 days
before the first dose of study treatment is permitted.
- Willingness and ability to comply with scheduled visits, treatment plans, laboratory
tests and other study procedures.
- Absence of any psychological, familial, sociological or geographical condition
potentially hampering compliance with the study protocol and follow-up schedule; those
conditions should be discussed with the patient before registration in the trial
- Women of child bearing potential (WOCBP) must have a negative serum pregnancy test
within 72 hours prior to the first dose of study treatment.
Note: women of childbearing potential are defined as premenopausal females capable of
becoming pregnant (ie, females who have had any evidence of menses in the past 12 months,
with the exception of those who had prior hysterectomy). However, women who have been
amenorrheic for 12 or more months are still considered to be of childbearing potential if
the amenorrhea is possibly due to prior chemotherapy, antiestrogens, low body weight,
ovarian suppression or other reasons.
- Patients of childbearing / reproductive potential should use adequate birth control
measures, as defined by the investigator, during the study treatment period and for at
least 4 months after the last study treatment. A highly effective method of birth
control is defined as a method which results in a low failure rate (i.e. less than 1%
per year) when used consistently and correctly.
- Before patient registration, written informed consent must be given according to ICH
(International Conference on Harmonisation)/GCP (Good clinical Practice), and
national/local regulations.
Exclusion Criteria:
- evidence of tumor invading the gastrointestinal tract (esophagus, stomach, small or
large bowel, rectum or anus) within 28 days prior to the first dose of cabozantinib.
- current evidence of endotracheal or endobronchial tumor within 28 days before the
first dose of cabozantinib.
- radiographic presence of a cavitating pulmonary lesion within 28 days prior to the
first dose of cabozantinib. patient with tumor in contact with, invading or encasing a
major blood vessel
- other prior tyrosine kinase inhibitors for the treatment of advanced GIST.
- other investigational agents within 28 days before the first dose of study treatment;
- specific contraindications for treatment with cabozantinib (e.g. no known immediate or
delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to
cabozantinib).
- poorly controlled hypertension defined at baseline as blood pressure (BP) >150/90
mmHg.
- cerebrovascular accident, no transient ischemic attack and no pulmonary embolism in
the past 6 months.
- gastrointestinal disorders associated with a high risk of perforation or fistula
formation within 28 days before the first dose of study treatment, including the
following:
- Known intra-abdominal tumor/metastases invading gastrointestinal mucosa.
- Active peptic ulcer disease.
- Inflammatory bowel disease (including ulcerative colitis and Crohn's disease),
diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis.
- Malabsorption syndrome.
- One of the following within 6 months before the first dose of study treatment:
- Clinically significant gastrointestinal bleeding.
- Abdominal fistula.
- Gastrointestinal perforation.
- Bowel obstruction.
- Gastric outlet obstruction.
- Intra-abdominal abscess (complete resolution of an intra-abdominal abscess must
be confirmed prior to initiating treatment with cabozantinib even if the abscess
occurred more than 6 months before the first dose of study treatment).
- other disorders associated with a high risk of fistula formation including PEG tube
placement within 3 months before the first dose of study therapy;
- evidence of significant active bleeding (including GI bleeding) or bleeding diathesis
within 6 months before the first dose of study treatment.
- hemoptysis = 0.5 teaspoon (2.5 ml) of red blood within 3 months before the first dose
of study treatment.
- signs indicative of pulmonary hemorrhage within 3 months before the first dose of
study treatment.
Note: patient with a prior history of hemoptysis associated with metastatic disease must
have a bronchoscopy to rule out endobronchial lesions. A patient with an endobronchial
tumor lesion is not eligible for the study.
- Prior surgery:
- prior major surgery or trauma within 12 weeks prior to first dose of study drug
and/or presence of any non-healing wound, fracture or ulcer. Complete wound
healing from major surgery must have occurred 1 month before the first dose of
study treatment.
- Patients with clinically relevant ongoing complications from prior surgery;
- Following clinically significant disorders such as:
- active infection requiring systemic treatment within 28 days before the first
dose of study treatment;
- history of organ transplant;
- concurrent uncompensated hypothyroidism or thyroid dysfunction within 7 days
before the first dose of study treatment.
- history of other malignancy in the past 5 years with the exception of treated
carcinoma in situ of the cervix and non-metastatic, non-melanoma skin cancer. Patients
with desmoid fibromatosis or neurofibromas, which can be associated with GIST, are
allowed to enter the trial, under the provision that they do have a measurable GIST
lesion that can be distinguished from the other lesions.
- Patients requiring chronic concomitant treatment with strong CYP3A4 inducers (eg,
dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, rifapentine,
phenobarbital, and St. John's Wort)
- Lactating females
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