Pre-operative Treatment With Erythropoietin and Iron Supplement in Cardiac Surgery

Anemia, Iron-Deficiency Clinical Trial

Official title: Pre-operative Treatment With Erythropoietin and Iron Supplement for Prevention of Perioperative Blood Transfusion in Cardiac Surgery

Status Terminated

Clinical Trial Summary

Pre-treatment of patients with erythropoietin subcutaneously and iron supplement intravenously, in order to create a clinical pathway to minimize transfusion of red blood cells in a selected group of cardiac patients with an increased risk for blood transfusions in our cardiac surgery program.

Clinical Trial Description

Blood transfusion is identified as an independent predictor of early mortality after Coronary artery bypass grafting operations In addition, female gender, lower body surface area (BSA), low preoperative Hemoglobin (Hb), previous cardiac surgery, emergency operation and low preoperative creatinin clearance were found to be independent risk factors for receiving Red Blood Cells (RBC) units.

We create a clinical pathway to reduce transfusion of red blood cells by pretreating patients with erythropoietin and iron to determine the reduction of number of patients who receive blood transfusion perioperatively. Also we want to investigate the decrease in the mean number of RBC units received per patient in the perioperative period. ;

Related Conditions & MeSH terms

• Anemia, Iron-Deficiency
• Heart; Dysfunction Postoperative, Cardiac Surgery

• NCT number: NCT02210949
• Study type: Interventional
• Source: Catharina Ziekenhuis Eindhoven
• Status: Terminated
• Phase: Phase 4
• Start date: August 2014
• Completion date: April 2017