Chronic Obstructive Airway Disease Clinical Trial
Official title:
A Pilot Study to Examine the Effect of Acute Exercise on Neutrophil Function in Patients With Chronic Obstructive Pulmonary Disease
Exercise is a cornerstone of pulmonary rehabilitation in the treatment of Chronic
Obstructive Pulmonary Disease (COPD). Although researchers have shown numerous benefits with
exercise in COPD patients, most studies have only looked at exercise tolerance and
psychological outcomes following training. COPD is characterised by persistent inflammation
that can cause progressive decline in lung function and multisystemic complications. This
inflammation can be amplified in patients when they suffer acute exacerbations. There is a
wellknown relationship between exercise, immune function and risk of infection. Exercise has
also been shown to have an antiinflammatory effect when performed regularly. There is a lack
of research looking into the inflammatory or immune response to exercise in patients with
COPD. The exercise within this study will be individually tailored to patients with COPD
based on their validated 6 minute walk test (6MWT) but the protocol will involve interval
exercise that has been used previously. This type of exercise is considered most appropriate
for research into mechanisms of benefit because it maintains the exercise training effects
of other modalities (e.g. continuous low intensity aerobic exercise) while avoiding the
occurrence of limitations to exercise in people with lung problems (e.g. dynamic
hyperinflation). It also closely mirrors daily activity of someone with COPD.
The investigators want to explore the effects of exercise specifically on immune function in
15 people COPD and compare any changes to 15 Controls. By better understanding the
mechanisms of how exercise affects inflammation, the investigators could eventually design
better Pulmonary Rehabilitation interventions, especially for those most at risk.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02527486 -
Seoul National University Airway Registry
|
N/A | |
| Completed |
NCT01443845 -
Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)
|
Phase 4 | |
| Withdrawn |
NCT00180765 -
Regulation of the Release of Inflammatory Mediators From Blood Leukocytes
|
||
| Withdrawn |
NCT01261377 -
Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)
|
Phase 1/Phase 2 | |
| Completed |
NCT01141842 -
Early Detection of Lung Tumors by Sniffer Dogs - Evaluation of Sensitivity and Specificity
|
Phase 1 | |
| Completed |
NCT01297790 -
Cough Responses to Tussive Agents in Health and Disease
|
N/A | |
| Completed |
NCT01347931 -
In-home Evaluation of a Noninvasive Open Ventilation System in Patients With Severe Respiratory Insufficiency
|
N/A | |
| Completed |
NCT01823627 -
Pulmonary Disease in a Psychiatric Inpatient Population
|
N/A | |
| Completed |
NCT01555593 -
Effect of Prolonged Decubitus on Nitric Oxide Concentration in Chronic Obstructive Pulmonary Disease
|
Phase 4 | |
| Withdrawn |
NCT00384566 -
A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure
|
Phase 4 | |
| Recruiting |
NCT03275116 -
The Effect of Twice Daily vs. Once Daily Bronchodilation on Hyperinflation in COPD Patients During 24 Hours.
|
Phase 4 | |
| Terminated |
NCT02061852 -
Evaluation of the Safety of the Medical Device Simeox®
|
N/A | |
| Completed |
NCT02209207 -
Continuous Versus Interval Walking Training in Patients With COPD - a Pilot Study
|
N/A | |
| Completed |
NCT01033487 -
A Study To Examine The Safety, Pharmacokinetics And Pharmacodynamics Of PF-03635659 In Patients With Chronic Obstructive Pulmonary Disease
|
Phase 2 | |
| Completed |
NCT02411383 -
Clinical Study to Investigate Safety and Performance of NeuRx DPS in Patients Undergoing Bilateral Lung Transplantation
|
N/A | |
| Completed |
NCT02042976 -
Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease
|
N/A | |
| Active, not recruiting |
NCT01923051 -
Czech Multicentre Research Database of Chronic Obstructive Pulmonary Disease (COPD)
|
||
| Completed |
NCT01355978 -
Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
|
N/A |