Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Endovascular Repair of Aortic Aneurysm Clinical Trial

Official title:

Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02107170
• Other study ID #: VIAEV
• Status: Completed
• Phase: Phase 4
• Start date: February 2014
• Est. completion date: December 2017

Study information

• Verified date: June 2018
• Source: First Affiliated Hospital, Sun Yat-Sen University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. The effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. In this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. Investigators will also observe whether changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6, are associated with postoperative delirium or cognitive change.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 68
• Est. completion date: December 2017
• Est. primary completion date: October 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

• age 18-100 years of age

• Patients presenting for Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities

Exclusion Criteria:

• Patients with pre-existing delirium

• Inablility to converse

Related Conditions & MeSH terms

• Aneurysm
• Aortic Aneurysm
• Arteriosclerosis
• Arteriosclerosis Obliterans
• Endovascular Repair of Aortic Aneurysm
• Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities

Intervention

Drug:
• Sevoflurane
sevoflurane-based general anesthesia
• Propofol
total intravenous anesthesia
• Remifentanil

Locations

Country	Name	City	State
China	First Affiliated Hospital, Sun Yat-Sen University	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Tao Zhang

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of patients with postoperative cognitive dysfunction		7 days after surgery
Secondary	Number of patients with postoperative cognitive dysfunction		3 months after surgery
Secondary	Changes in plasma levels of VEGF, TGF-1, TNF-a, IL-1ß, and IL-6 (a composite outcome measure)		3 days after surgery