A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Local Infiltration Analgesia for Postoperative Analgesia After Total Knee Arthroplasty

Analgesia in Total Knee Arthroplasty Clinical Trial

Official title:

A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Local Infiltration Analgesia for Postoperative Analgesia After Total Knee Arthroplasty

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02104934
• Other study ID #: CGHLIAACB2013
• Status: Completed
• Phase: N/A
• First received: March 18, 2014
• Last updated: April 24, 2017
• Start date: March 2014
• Est. completion date: March 2016

Study information

• Verified date: July 2015
• Source: Changi General Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Total knee arthroplasty or replacement (TKA), a commonly performed surgery for osteoarthritis of the knee, is a painful procedure and requires a multimodal analgesic approach. A method for analgesia is local infiltration analgesia (LIA), where a mixture of drugs is injected around the knee joint.

Adductor canal block (ACB) is an alternative regional anaesthesia technique which has been shown to result in minimal thigh weakness.

The investigators aim to study if the analgesia provided by ACB is superior to LIA while preserving quadriceps strength.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: March 2016
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 45 Years to 85 Years

Eligibility

Inclusion Criteria:

• Patients scheduled for primary TKA under single shot spinal anaesthesia, between ages 45-85 years old, American Society of Anesthesiologists (ASA) physical status 1 to 3 and BMI 18-35 kg/m2

Exclusion Criteria:

• Patients unable to give consent, inability to communicate/ cooperate, patients with regular consumption of strong opioids (morphine, oxycodone) or steroids, allergy to local anaesthetics or any drugs included in the study, patients with lower limb surgery in the preceding year, patients with pre-existing neurological deficits and patients who have contraindications for spinal anaesthesia.

Related Conditions & MeSH terms

• Analgesia in Total Knee Arthroplasty

Intervention

Procedure:
• Adductor Canal Block

Locations

Country	Name	City	State
Singapore	Changi General Hospital	Singapore

Sponsors (1)

Lead Sponsor	Collaborator
Changi General Hospital

Country where clinical trial is conducted

Singapore, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Presence of Complications	Hematoma, wound infection, neurological deficits, any incidence of fall	up to 48 hours
Other	Length of Hospital Stay	Number of days till discharge	Up to 30 days
Primary	Morphine consumption in the first 24 hours	morphine consumption in the first 24 hours (including morphine administered in recovery and via PCA).	24 hours
Secondary	Pain Scores	Pain scores are recorded at 1, 6, 12, 24 and 48 hours post-operatively, assessed using a visual analog scale (0-100mm) at rest and during 45 degree passive flexion of knee.	1, 6, 12, 24 hours; up to 48 hours postoperative
Secondary	Morphine Consumption	The balance usage after primary outcome	At 48 hours
Secondary	Postoperative Nausea and Vomiting	Presence/absence of nausea and vomiting, and total number of episodes of vomiting	Up to 48 hours
Secondary	Sedation Scores		Up to 48 hours
Secondary	Quadriceps Strength		at 24 and 48 hours